Pneumococcal surface proteins: when the whole is greater than the sum of its parts

I Pérez‐Dorado, S Galan‐Bartual… - Molecular oral …, 2012 - Wiley Online Library
Surface‐exposed proteins of pathogenic bacteria are considered as potential virulence
factors through their direct contribution to host–pathogen interactions. Four families of …

Role of two-component systems in the virulence of Streptococcus pneumoniae

GK Paterson, CE Blue… - Journal of medical …, 2006 - microbiologyresearch.org
Understanding of how the human pathogen Streptococcus pneumoniae perceives and
responds to its environment in the host offers insight into the pathogenesis of disease …

mRNA differential display in a microbial enrichment culture: simultaneous identification of three cyclohexanone monooxygenases from three species

PC Brzostowicz, DM Walters, SM Thomas… - Applied and …, 2003 - Am Soc Microbiol
ABSTRACT mRNA differential display has been used to identify cyclohexanone oxidation
genes in a mixed microbial community derived from a wastewater bioreactor. Thirteen DNA …

A two‐component system that controls the expression of pneumococcal surface antigen A (PsaA) and regulates virulence and resistance to oxidative stress in …

J McCluskey, J Hinds, S Husain, A Witney… - Molecular …, 2004 - Wiley Online Library
Recent genomic‐based studies have identified 13 two‐component signal transduction
systems (TCS) in Streptococcus pneumoniae. Bacterial TCSs are important for regulating …

Phosphate-containing polyethylene glycol polymers prevent lethal sepsis by multidrug-resistant pathogens

A Zaborin, JR Defazio, M Kade… - Antimicrobial agents …, 2014 - Am Soc Microbiol
Antibiotic resistance among highly pathogenic strains of bacteria and fungi is a growing
concern in the face of the ability to sustain life during critical illness with advancing medical …

Effects of Deletion of the Streptococcus pneumoniae Lipoprotein Diacylglyceryl Transferase Gene lgt on ABC Transporter Function and on Growth In Vivo

S Chimalapati, JM Cohen, E Camberlein… - PloS one, 2012 - journals.plos.org
Lipoproteins are an important class of surface associated proteins that have diverse roles
and frequently are involved in the virulence of bacterial pathogens. As prolipoproteins are …

Physiological Roles of the Dual Phosphate Transporter Systems in Low and High Phosphate Conditions and in Capsule Maintenance of Streptococcus pneumoniae …

JJ Zheng, D Sinha, KJ Wayne… - Frontiers in Cellular and …, 2016 - frontiersin.org
Unlike most bacteria, Streptococcus pneumoniae (pneumococcus) has two evolutionarily
distinct ABC transporters (Pst1 and Pst2) for inorganic phosphate (Pi) uptake. The genes …

The high-affinity phosphate transporter Pst in Proteus mirabilis HI4320 and its importance in biofilm formation

GA O'May, SM Jacobsen, M Longwell… - …, 2009 - microbiologyresearch.org
Proteus mirabilis causes urinary tract infections (UTIs) in individuals requiring long-term
indwelling catheterization. The pathogenesis of this uropathogen is mediated by a number …

Bacterial surface lipoproteins mediate epithelial microinvasion by Streptococcus pneumoniae

JM Chan, E Ramos-Sevillano, M Betts… - Infection and …, 2024 - Am Soc Microbiol
Streptococcus pneumoniae, a common colonizer of the upper respiratory tract, invades
nasopharyngeal epithelial cells without causing disease in healthy participants of controlled …

Regions of Diversity 8, 9 and 13 contribute to Streptococcus pneumoniae virulence

A Embry, E Hinojosa, CJ Orihuela - BMC microbiology, 2007 - Springer
Background Streptococcus pneumoniae is the leading cause of community-acquired
pneumonia. Previously, using comparative genomic analyses, 13 regions of genomic …