Cu-catalysed arylation reactions devoted to the formation of C–C and C–heteroatom bonds
(Ullmann-type couplings) have acquired great importance in the last decade. This review …

Phenols and phenol derivatives serve as synthetic building blocks for the construction of
compounds ranging from polymers to pharmaceuticals. Despite numerous methods for …

The combination of Cu (acac) 2 and N, N′-bis (4-hydroxyl-2, 6-dimethylphenyl) oxalamide
(BHMPO) provides a powerful catalytic system for hydroxylation of (hetero) aryl halides. A …

A highly effective hydroxylation reaction of aryl halides with water under synergistic
organophotoredox and nickel catalysis is reported. The OH group of the resulting phenols …

For more than a century, copper has been used as a promoter in cross-coupling reactions of
aryl halides with diverse nucleophiles to construct C–C and C-heteroatom bonds. The …

The conversion of aryl halides to phenols under mild reaction conditions is a longstanding
and formidable challenge in organic chemistry. Herein, we report the rational design of a …

The first total synthesis of spirobacillene A, an indole alkaloid isolated from Lysinibacillus
fusiformis, is reported. A Lewis acid mediated spirocyclization of an anisole derivative onto a …

The efficient conversion of aryl halides to phenols under mild reaction conditions remains a
great challenge. Here we demonstrate that a facile and efficient hydroxylation reaction of …

A clean process has been developed for the ipso-hydroxylation of aryl and heteroaryl
boronic acids to the corresponding phenols using commercially available and recyclable …

Parallel synthesis and mass-directed purification of a modular ligand library, high-
throughput experimentation, and rational ligand evolution have led to a novel copper …