Streptococcus pyogenes, also known as group A Streptococcus (GAS), causes mild human
infections such as pharyngitis and impetigo and serious infections such as necrotizing …

The cell wall envelope of gram-positive bacteria is a macromolecular, exoskeletal organelle
that is assembled and turned over at designated sites. The cell wall also functions as a …

Recent work from several laboratories has demonstrated that proteolytic mechanisms
significantly contribute to the molecular interplay between Streptococcus pyogenes, an …

Streptococcus pyogenes is an important human pathogen that selectively interacts with
proteins involved in the humoral defense system, such as immunoglobulins and …

Discusses the role of bacterial proteinases in matrix destruction and modulation of host
responses. Evasion of host defense mechanisms; Mechanism of gingipain inference with …

Increased vascular permeability is a key feature of inflammatory conditions. In severe
infections, leakage of plasma from the vasculature induces a life-threatening hypotension …

The human pathogen Streptococcus pyogenes possesses a chromosomal region, the mga
regulon, that contains co-regulated genes important to the virulence of these bacteria. A …

Group A streptococcus (Streptococcus pyogenes) is an exclusively human pathogen that
causes a wide spectrum of diseases ranging from pharyngitis, to impetigo, to toxic shock, to …

The ability of numerous microorganisms to cause disease relies upon the highly regulated
expression of secreted proteinases. In this study, mutagenesis with a novel derivative of …

Some isolates of the significant human pathogenStreptococcus pyogenes, including virulent
strains of the M1 serotype, secrete protein SIC. This molecule, secreted in large quantities …