Genomic instability is the hallmark of various cancers with the increasing accumulation of
DNA damage. The application of radiotherapy and chemotherapy in cancer treatment is …

Colorectal cancer (CRC) represents the second leading cause of cancer-related deaths
worldwide. The pathogenesis of CRC is a complex multistep process. Among other factors …

Simple Summary The transcription factor p53 is a crucial tumor suppressor that regulates
diverse cellular responses to protect against cancer development. Deactivating p53 …

Reprogramming of cellular metabolism is a hallmark of cancer. Cancer cells undergo
metabolic adaptations to maintain tumorigenicity and survive under the attack of immune …

Epidemiological studies indicate that chronic obstructive pulmonary disease (COPD) is
associated with the incidence of changes in intestinal health. Cigarette smoking, as one of …

Scope Butyrate (B) is a short‐chain fatty acid produced by dietary fiber, known to inhibit
histone deacetylases (HDACs) and possess cancer‐preventive/anticancer effects. However …

Background Colorectal cancer liver metastases (CRCLM) are associated with a poor
prognosis, reflected by a five-year survival rate of 14%. Anti-angiogenic therapy through anti …

There are limited options for patients who develop liver metastasis from colorectal cancer
(CRC), the leading cause of cancer-related mortality worldwide. Emerging evidence has …

Oxidative stress (OS) arises when the body is subjected to harmful endogenous or
exogenous factors that overwhelm the antioxidant system. There is increasing evidence that …

Colorectal carcinoma (CRC) represents the fourth most common cancer worldwide and is
the third most common cause of malignancy-associated mortality. Distant metastases to the …