In the last decades, transcriptome profiling has been one of the most utilized approaches to
investigate human diseases at the molecular level. Through expression studies, many …

Highlights•RNA-seq is emerging as a powerful technology to study alternative splicing.•RNA
mis-splicing can cause cancers and a variety of other human diseases.•To target alternative …

Dysregulation of pre-mRNA splicing is a common hallmark of cancer cells and it is
associated with altered expression, localization, and mutations of the components of the …

Therapeutics that directly target RNAs are promising for a broad spectrum of disorders,
including the neurodegenerative diseases. This is exemplified by the FDA approval of …

Animals possess a wide variety of muscle types that support different kinds of movements.
Different muscles have distinct locations, morphologies and contractile properties, raising …

In recent years, the RNA molecule became one of the most promising targets for therapeutic
intervention. Currently, a large number of RNA-based therapeutics are being investigated …

Long non-coding (lnc) RNAs serve important cellular functions and certain lncRNAs have
roles in different mechanisms of gene regulation. lncRNA-antisense non-coding RNA in the …

Background: Alternative splicing events have been increasingly reported for anomalous
perturbations in various cancers, including papillary thyroid cancer (PTC). Methods …

The discovery that XDP is linked to a polymorphic hexameric sequence suggests that it
could share mechanisms with other DNA repeat disorders, whereas the transcriptional …

For more than three decades, researchers have known that consensus splice sites alone are
not sufficient regulatory elements to provide complex splicing regulation. Other regulators …