Glial cells have a variety of functions in the brain, ranging from immune defense against
external and endogenous hazardous stimuli, regulation of synaptic formation, calcium …

Targeting the amyloid‐β (Aβ) peptide cascade has been at the heart of therapeutic
developments in Alzheimer's disease (AD) research for more than 25 years, yet no …

Lipids, proteins and DNA in the central nervous system have a high sensitivity to oxidative
stress. Reactive oxygen species (ROS)-induced damage increases with aging, especially in …

Proteasomes are multisubunit complexes that catalyze the majority of protein degradation in
mammalian cells to maintain protein homeostasis and influence the regulation of most …

The homeostasis of cellular proteins, or proteostasis, is critical for neuronal function and for
brain processes, including learning and memory. Increasing evidence indicates that …

Amyloid-beta (Abeta) peptide is the original causative factor of Alzheimer's disease (AD)
according to the amyloid cascade hypothesis. The ubiquitin–proteasome system (UPS), the …

Significance: Alzheimer's disease is a neurodegenerative disorder that is projected to
exceed more than 100 million cases worldwide by 2050. Aging is considered the primary …

The ubiquitin proteasome system (UPS) is crucial for intracellular protein homeostasis and
for degradation of aberrant and damaged proteins. The accumulation of ubiquitinated …

Several lines of evidence have shown that defects in the endo-lysosomal autophagy
degradation pathway and the ubiquitin-proteasome system play a role in Alzheimer's …

Alzheimer's disease (AD) represents the most common form of dementia, characterized by
amyloid β (Aβ) plaques and neurofibrillary tangles (NFTs). It is characterized by …