Intra-articular drug delivery has a number of advantages over systemic administration;
however, for the past 20 years, intra-articular treatment options for the management of knee …

Osteoarthritis (OA) is a prevalent chronic whole-joint disease characterized by low-grade
systemic inflammation, degeneration of joint-related tissues such as articular cartilage, and …

The essential physiological role of platelets in wound healing and tissue repair builds the
rationale for the use of human platelet derivatives in regenerative medicine. Abundant …

There is a significant burden of disease associated with bone defects, and their
management is challenging. These injuries have a profound clinical and economic impact …

Background Quite a few randomized controlled trials (RCTs) investigating the efficacy of
platelet-rich plasma (PRP) for treatment of knee osteoarthritis (OA) have been recently …

Background: Leukocyte-poor platelet-rich plasma (LP-PRP) is hypothesized to be more
suitable for intra-articular injection than leukocyte-rich PRP (LR-PRP) in the treatment of …

Platelet rich plasma (PRP) represents a relatively new approach in regenerative medicine. It
is obtained from patient's own blood and contains different growth factors and other …

Background Platelet-rich plasma (PRP) provides a nonsurgical approach for treating
osteoarthritis (OA). Exosomes that play vital roles in intercellular communication have been …

Tendon injuries are common and debilitating, with non-regenerative healing often resulting
in chronic disease. While there has been considerable progress in identifying the cellular …

Background: Variations in formulations used to prepare platelet-rich plasmas (PRPs) result
in differences in the cellular composition and biomolecular characteristics. Purpose: To …