Multidrug-resistant bacteria are a severe threat to public health. Conventional antibiotics are
becoming increasingly ineffective as a result of resistance, and it is imperative to find new …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Motivation: Molecular representation for small molecules has been routinely used in
QSAR/SAR, virtual screening, database search, ranking, drug ADME/T prediction and other …

Antioxidative peptides have attracted increasing attention from researchers because of their
antioxidant properties as natural materials in functional food and for applications in …

Ability of quantitative structure–property/activity relationships (QSPRs/QSARs) to serve for
epistemological processes in natural sciences is discussed. Some weirdness of …

Multi-target drugs against selective multiple targets improve therapeutic efficacy, safety and
resistance profiles by collective regulations of a primary therapeutic target together with …

Multi-target drugs against particular multiple targets get better protection, resistance profiles
and curative influence by cooperative rules of a key beneficial target with resistance …

Owing to their unique functions in regulating glucose, lipid and cholesterol metabolism,
PPARs (peroxisome proliferator-activated receptors) have drawn special attention for …

There are many of pathogen parasite species with different susceptibility profile to
antiparasitic drugs. Unfortunately, almost QSAR models predict the biological activity of …

The cannabinoid receptor subtype 2 (CB2R) represents an interesting and new therapeutic
target for its involvement in the first steps of neurodegeneration as well as in cancer onset …