Structural and functional comparison of magnesium transporters throughout evolution
GAC Franken, MA Huynen, LA Martínez-Cruz… - Cellular and Molecular …, 2022 - Springer
Abstract Magnesium (Mg2+) is the most prevalent divalent intracellular cation. As co-factor in
many enzymatic reactions, Mg2+ is essential for protein synthesis, energy production, and …
many enzymatic reactions, Mg2+ is essential for protein synthesis, energy production, and …
Sperm ion transporters and channels in human asthenozoospermia: genetic etiology, lessons from animal models, and clinical perspectives
E Cavarocchi, M Whitfield, F Saez, A Touré - International journal of …, 2022 - mdpi.com
In mammals, sperm fertilization potential relies on efficient progression within the female
genital tract to reach and fertilize the oocyte. This fundamental property is supported by the …
genital tract to reach and fertilize the oocyte. This fundamental property is supported by the …
The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics
A Kollewe, V Chubanov, FT Tseung, L Correia… - Elife, 2021 - elifesciences.org
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously
expressed membrane protein consisting of ion channel and protein kinase domains. TRPM7 …
expressed membrane protein consisting of ion channel and protein kinase domains. TRPM7 …
CNNM proteins selectively bind to the TRPM7 channel to stimulate divalent cation entry into cells
Magnesium is essential for cellular life, but how it is homeostatically controlled still remains
poorly understood. Here, we report that members of CNNM family, which have been …
poorly understood. Here, we report that members of CNNM family, which have been …
Crystal structure of an archaeal CorB magnesium transporter
CNNM/CorB proteins are a broadly conserved family of integral membrane proteins with
close to 90,000 protein sequences known. They are associated with Mg2+ transport but it is …
close to 90,000 protein sequences known. They are associated with Mg2+ transport but it is …
[HTML][HTML] Recent advances in the structural biology of Mg2+ channels and transporters
Abstract Magnesium ions (Mg 2+) are the most abundant divalent cations in living organisms
and are essential for various physiological processes, including ATP utilization and the …
and are essential for various physiological processes, including ATP utilization and the …
PRL-1/2 phosphatases control TRPM7 magnesium-dependent function to regulate cellular bioenergetics
S Hardy, Y Zolotarov, J Coleman… - Proceedings of the …, 2023 - National Acad Sciences
Phosphatases of regenerating liver (PRL-1, PRL-2, PRL-3; also known as PTP4A1, PTP4A2,
PTP4A3, respectively) control intracellular magnesium levels by interacting with the CNNM …
PTP4A3, respectively) control intracellular magnesium levels by interacting with the CNNM …
Molecular mechanisms of renal magnesium reabsorption
DH Ellison, Y Maeoka… - Journal of the American …, 2021 - journals.lww.com
Magnesium is an essential cofactor in many cellular processes, and aberrations in
magnesium homeostasis can have life-threatening consequences. The kidney plays a …
magnesium homeostasis can have life-threatening consequences. The kidney plays a …
Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism
S Hardy, E Kostantin, SJ Wang… - Proceedings of the …, 2019 - National Acad Sciences
Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1,
PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the …
PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the …
Physiological and oncogenic roles of the PRL phosphatases
S Hardy, E Kostantin, T Hatzihristidis… - The FEBS …, 2018 - Wiley Online Library
The human Phosphatase of Regenerative Liver (PRL) family comprises three members
(PRL‐1,‐2,‐3; gene name PTP 4A1, PTP 4A2, PTP 4A3) that are highly expressed in a …
(PRL‐1,‐2,‐3; gene name PTP 4A1, PTP 4A2, PTP 4A3) that are highly expressed in a …