Structural and functional comparison of magnesium transporters throughout evolution

GAC Franken, MA Huynen, LA Martínez-Cruz… - Cellular and Molecular …, 2022 - Springer
Abstract Magnesium (Mg2+) is the most prevalent divalent intracellular cation. As co-factor in
many enzymatic reactions, Mg2+ is essential for protein synthesis, energy production, and …

Sperm ion transporters and channels in human asthenozoospermia: genetic etiology, lessons from animal models, and clinical perspectives

E Cavarocchi, M Whitfield, F Saez, A Touré - International journal of …, 2022 - mdpi.com
In mammals, sperm fertilization potential relies on efficient progression within the female
genital tract to reach and fertilize the oocyte. This fundamental property is supported by the …

The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics

A Kollewe, V Chubanov, FT Tseung, L Correia… - Elife, 2021 - elifesciences.org
The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously
expressed membrane protein consisting of ion channel and protein kinase domains. TRPM7 …

CNNM proteins selectively bind to the TRPM7 channel to stimulate divalent cation entry into cells

Z Bai, J Feng, GAC Franken, N Al'Saadi, N Cai… - PLoS …, 2021 - journals.plos.org
Magnesium is essential for cellular life, but how it is homeostatically controlled still remains
poorly understood. Here, we report that members of CNNM family, which have been …

Crystal structure of an archaeal CorB magnesium transporter

YS Chen, G Kozlov, BE Moeller, A Rohaim… - Nature …, 2021 - nature.com
CNNM/CorB proteins are a broadly conserved family of integral membrane proteins with
close to 90,000 protein sequences known. They are associated with Mg2+ transport but it is …

[HTML][HTML] Recent advances in the structural biology of Mg2+ channels and transporters

F Jin, Y Huang, M Hattori - Journal of Molecular Biology, 2022 - Elsevier
Abstract Magnesium ions (Mg 2+) are the most abundant divalent cations in living organisms
and are essential for various physiological processes, including ATP utilization and the …

PRL-1/2 phosphatases control TRPM7 magnesium-dependent function to regulate cellular bioenergetics

S Hardy, Y Zolotarov, J Coleman… - Proceedings of the …, 2023 - National Acad Sciences
Phosphatases of regenerating liver (PRL-1, PRL-2, PRL-3; also known as PTP4A1, PTP4A2,
PTP4A3, respectively) control intracellular magnesium levels by interacting with the CNNM …

Molecular mechanisms of renal magnesium reabsorption

DH Ellison, Y Maeoka… - Journal of the American …, 2021 - journals.lww.com
Magnesium is an essential cofactor in many cellular processes, and aberrations in
magnesium homeostasis can have life-threatening consequences. The kidney plays a …

Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism

S Hardy, E Kostantin, SJ Wang… - Proceedings of the …, 2019 - National Acad Sciences
Phosphatases of regenerating liver (PRL-1, PRL-2, and PRL-3, also known as PTP4A1,
PTP4A2, and PTP4A3) control magnesium homeostasis through an association with the …

Physiological and oncogenic roles of the PRL phosphatases

S Hardy, E Kostantin, T Hatzihristidis… - The FEBS …, 2018 - Wiley Online Library
The human Phosphatase of Regenerative Liver (PRL) family comprises three members
(PRL‐1,‐2,‐3; gene name PTP 4A1, PTP 4A2, PTP 4A3) that are highly expressed in a …