Disclosures: Dr. Labaki, ACP Contributing Author, reports nonfinancial support from
Pulmonx and personal fees from Konica Minolta outside the submitted work. Dr. Rosenberg …

Alpha1-Antitrypsin Deficiency AAT is a protease inhibitor targeting neutrophil elastase. It
prevents the destruction of tissue, particularly in the lung, from elastase activity. AAT …

Abstract The Spanish COPD Guidelines (GesEPOC) were first published in 2012, and since
then have undergone a series of updates incorporating new evidence on the diagnosis and …

This Executive Summary of the Global Strategy for the Diagnosis, Management, and
Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 …

Neutrophil elastase (NE) is a major inflammatory protease released by neutrophils and is
present in the airways of patients with cystic fibrosis (CF), chronic obstructive pulmonary …

Chronic obstructive pulmonary disease (COPD) is the end result of a series of dynamic and
cumulative gene–environment interactions over a lifetime. The evolving understanding of …

Abstract α1-Antitrypsin deficiency (A1ATD) is an inherited disorder caused by mutations in
SERPINA1, leading to liver and lung disease. It is not a rare disorder but frequently goes …

Quantitative analysis of thin-section CT of the chest has a growing role in the clinical
evaluation and management of diffuse lung diseases. This heterogeneous group includes …

In many respiratory diseases characterized by an intense inflammatory response, the
balance between proteolytic enzymes (proteases, including elastases) and their inhibitors …

Background: The diagnosis and clinical management of adults with alpha-1 antitrypsin
deficiency (AATD) have been the subject of ongoing debate, ever since the publication of …