Angiogenesis plays a critical role within the human body, from the early stages of life (ie,
embryonic development) to life-threatening diseases (eg, cancer, heart attack, stroke, wound …

The role of inflammation in carcinogenesis has been extensively investigated and well
documented. Many biochemical processes that are altered during chronic inflammation …

Abstract Background Cancer‐associated fibroblasts (CAFs) play an important role in the
induction of chemo‐resistance. This study aimed to clarify the mechanism underlying CAF …

Osteopontin (OPN) is a glyco-phosphoprotein that is expressed and secreted by numerous
human cancers. OPN functions in cell adhesion, chemotaxis, macrophage-directed …

Osteopontin is a secreted phosphoprotein that has been implicated as an important
mediator of tumor metastasis and has been investigated for use as a biomarker for …

The family of matricellular proteins comprises molecules with disparate biology. The main
characteristic of matricellular proteins is to be expressed during tissue renewal and repair in …

Matrix metalloproteinases (MMPs) are critical for development wound healing and for the
progression of cancer. It is generally accepted that MMPs are secreted in a latent form …

Background We previously reported the role of IL-6 in a murine model of cancer cachexia
and currently documented a patient in whom tocilizumab, anti-IL-6 receptor antibody …

Vitamins and minerals serve essential roles in cellular metabolism, maintenance and growth
throughout life. They are also central components of many enzymes and transcription …

Multiple myeloma (MM) was the first haematological malignancy in which a prognostic
relevance of bone marrow microvessel density (MVD) was shown. Myeloma-induced …