The intracellular parasite Toxoplasma gondii has long provided a tractable experimental
system to investigate how the immune system deals with intracellular infections. This review …

Toxoplasma gondii is an obligate intracellular parasite and the causative agent of
Toxoplasmosis. A key to understanding and treating the disease lies with determining how …

Toxoplasma gondii is a parasitic protist infecting a wide group of warm-blooded animals,
ranging from birds to humans. While this infection is usually asymptomatic in healthy …

Toxoplasma gondii is a parasite that replicates within a specialized compartment called the
parasitophorous vacuole (PV), which is surrounded by the PV membrane (PVM). To obtain …

Toxoplasma gondii secretes protein effectors to subvert the human immune system
sufficiently to establish a chronic infection. Relative to murine infections, little is known about …

Examining host–pathogen interactions in animals can capture aspects of infection that are
obscured in cell culture. Using CRISPR-based screens, we functionally profile the entire …

Toxoplasma virulence depends on its ability to evade or survive the toxoplasmacidal
mechanisms induced by interferon gamma (IFNγ). While many Toxoplasma genes involved …

Upon pathogen detection, macrophages normally stay sessile in tissues while dendritic cells
(DCs) migrate to secondary lymphoid tissues. The obligate intracellular protozoan …

Secreted virulence factors of Toxoplasma to survive in immune-competent hosts have been
extensively explored by classical genetics and in vivo CRISPR screen methods, whereas …

Intracellular pathogens and other endosymbionts reprogram host cell transcription to
suppress immune responses and recalibrate biosynthetic pathways. This reprogramming is …