The present invention relates to peptides, proteins, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the immuno …

ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C ([C@ H](NC (=
O)[C@ H](C (C) C) NC (= O) CNC (= O)[C@ H](CCC (O)= O) NC (= O)[C@ H](CCCNC (N) …

The ligand of Numb protein-X (LNX) family, also known as the PDZRN family, is composed
of four discrete RING-type E3 ubiquitin ligases (LNX1, LNX2, LNX3, and LNX4), and LNX5 …

Ligand of NUMB Protein X1 and X2 (LNX1 and LNX2) are E3 ubiquitin ligases, named for
their ability to interact with and promote the degradation of the cell fate determinant protein …

Inflammation is essential for healthy immune function, wound healing, and resolution of
infection. RIG-I is a key RNA sensor that initiates an immune response, with activation and …

Ubiquitin chains linked through lysine63 (K63) play a critical role in inflammatory signalling.
Following ligand engagement of immune receptors, the RING E3 ligase TRAF6 builds K63 …

The HECT family of E3 ubiquitin ligase is divided into three subfamilies: the NEDD4, the
HERC, and the 'other'. Previous studies have mostly targeted members of the NEDD4 …

We investigated the genome of a 5-year-old male who presented with global developmental
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …

The HECT E3 ligase family comprises three subfamilies: NEDD4 E3 ubiquitin protein ligase
(NEDD4), HECT and RLD domain–containing E3 ubiquitin protein ligase (HERC), and" …

The activity of RING ubiquitin ligases (E3s) depends on an interaction between the RING
domain and ubiquitin conjugating enzymes (E2), but posttranslational events or additional …