In this review, we highlight the current understanding of translation elongation and recoding
in eukaryotes. In addition to providing an overview of the process, recent advances in our …

Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …

Methylation is a well‐known structural modification in organic and medicinal chemistry. This
review summarizes recent advances in methylation by categorizing specific methylation …

Recent advances in understanding different RNAs and unique features of their biology have
revealed a wealth of information. However, approaches to identify small molecules that …

Genetic decoding is not 'frozen'as was earlier thought, but dynamic. One facet of this is
frameshifting that often results in synthesis of a C-terminal region encoded by a new frame …

In the field of medicinal chemistry, the precise installation of a trideuteromethyl group is
gaining ever‐increasing attention. Site‐selective incorporation of the deuterated “magic …

Abstract SARS-CoV-2 uses− 1 programmed ribosomal frameshifting (− 1 PRF) to control
expression of key viral proteins. Because modulating− 1 PRF can attenuate the virus …

The majority of antivirals available target viral proteins; however, RNA is emerging as a new
and promising antiviral target due to the presence of highly structured RNA in viral genomes …

Methicillin-resistant Staphylococcus aureus (MRSA) presents one of the most serious health
concerns worldwide. The WHO labeled it as a “high-priority” pathogen in 2017, also citing …

Over the past decade, the RNA revolution has revealed thousands of non-coding RNAs that
are essential for cellular regulation and are misregulated in disease. While the development …