Translation elongation and recoding in eukaryotes
In this review, we highlight the current understanding of translation elongation and recoding
in eukaryotes. In addition to providing an overview of the process, recent advances in our …
in eukaryotes. In addition to providing an overview of the process, recent advances in our …
Targeting mRNA processing as an anticancer strategy
J Desterro, P Bak-Gordon… - Nature Reviews Drug …, 2020 - nature.com
Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …
Recent advances in methylation: a guide for selecting methylation reagents
Y Chen - Chemistry–A European Journal, 2019 - Wiley Online Library
Methylation is a well‐known structural modification in organic and medicinal chemistry. This
review summarizes recent advances in methylation by categorizing specific methylation …
review summarizes recent advances in methylation by categorizing specific methylation …
[HTML][HTML] The emerging role of RNA as a therapeutic target for small molecules
CM Connelly, MH Moon, JS Schneekloth - Cell chemical biology, 2016 - cell.com
Recent advances in understanding different RNAs and unique features of their biology have
revealed a wealth of information. However, approaches to identify small molecules that …
revealed a wealth of information. However, approaches to identify small molecules that …
Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use
Genetic decoding is not 'frozen'as was earlier thought, but dynamic. One facet of this is
frameshifting that often results in synthesis of a C-terminal region encoded by a new frame …
frameshifting that often results in synthesis of a C-terminal region encoded by a new frame …
The Deuterated “Magic Methyl” Group: A Guide to Site‐Selective Trideuteromethyl Incorporation and Labeling by Using CD3 Reagents
J Steverlynck, R Sitdikov… - Chemistry–A European …, 2021 - Wiley Online Library
In the field of medicinal chemistry, the precise installation of a trideuteromethyl group is
gaining ever‐increasing attention. Site‐selective incorporation of the deuterated “magic …
gaining ever‐increasing attention. Site‐selective incorporation of the deuterated “magic …
Anti-frameshifting ligand active against SARS coronavirus-2 is resistant to natural mutations of the frameshift-stimulatory pseudoknot
Abstract SARS-CoV-2 uses− 1 programmed ribosomal frameshifting (− 1 PRF) to control
expression of key viral proteins. Because modulating− 1 PRF can attenuate the virus …
expression of key viral proteins. Because modulating− 1 PRF can attenuate the virus …
[HTML][HTML] Small molecules targeting viral RNA
G Mathez, V Cagno - International Journal of Molecular Sciences, 2023 - mdpi.com
The majority of antivirals available target viral proteins; however, RNA is emerging as a new
and promising antiviral target due to the presence of highly structured RNA in viral genomes …
and promising antiviral target due to the presence of highly structured RNA in viral genomes …
Targeting Virulence in Staphylococcus aureus by Chemical Inhibition of the Accessory Gene Regulator System In Vivo
Methicillin-resistant Staphylococcus aureus (MRSA) presents one of the most serious health
concerns worldwide. The WHO labeled it as a “high-priority” pathogen in 2017, also citing …
concerns worldwide. The WHO labeled it as a “high-priority” pathogen in 2017, also citing …
Insights into the development of chemical probes for RNA
Over the past decade, the RNA revolution has revealed thousands of non-coding RNAs that
are essential for cellular regulation and are misregulated in disease. While the development …
are essential for cellular regulation and are misregulated in disease. While the development …