Nuclear compartmentalization as a mechanism of quantitative control of gene expression
Gene regulation requires the dynamic coordination of hundreds of regulatory factors at
precise genomic and RNA targets. Although many regulatory factors have specific affinity for …
precise genomic and RNA targets. Although many regulatory factors have specific affinity for …
Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate
Stem cells respond to nanoscale surface features, with changes in cell growth and
differentiation mediated by alterations in cell adhesion. The interaction of nanotopographical …
differentiation mediated by alterations in cell adhesion. The interaction of nanotopographical …
Nuclear lamins: thin filaments with major functions
R de Leeuw, Y Gruenbaum, O Medalia - Trends in cell biology, 2018 - cell.com
The nuclear lamina is a nuclear peripheral meshwork that is mainly composed of nuclear
lamins, although a small fraction of lamins also localizes throughout the nucleoplasm …
lamins, although a small fraction of lamins also localizes throughout the nucleoplasm …
Endoplasmic reticulum structure and interconnections with other organelles
AR English, GK Voeltz - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
The endoplasmic reticulum (ER) is a large, continuous membrane-bound organelle
comprised of functionally and structurally distinct domains including the nuclear envelope …
comprised of functionally and structurally distinct domains including the nuclear envelope …
LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins
BA Sosa, A Rothballer, U Kutay, TU Schwartz - Cell, 2012 - cell.com
Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the nuclear envelope
and are composed of KASH and SUN proteins residing in the outer and inner nuclear …
and are composed of KASH and SUN proteins residing in the outer and inner nuclear …
Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges
DA Starr, HN Fridolfsson - Annual review of cell and …, 2010 - annualreviews.org
The nuclear envelope links the cytoskeleton to structural components of the nucleus. It
functions to coordinate nuclear migration and anchorage, organize chromatin, and aid …
functions to coordinate nuclear migration and anchorage, organize chromatin, and aid …
Intermediate filaments: from cell architecture to nanomechanics
H Herrmann, H Bär, L Kreplak, SV Strelkov… - … reviews Molecular cell …, 2007 - nature.com
Intermediate filaments (IFs) constitute a major structural element of animal cells. They build
two distinct systems, one in the nucleus and one in the cytoplasm. In both cases, their major …
two distinct systems, one in the nucleus and one in the cytoplasm. In both cases, their major …
Nuclear lamins
T Dechat, SA Adam, P Taimen… - Cold Spring …, 2010 - cshperspectives.cshlp.org
The nuclear lamins are type V intermediate filament proteins that are critically important for
the structural properties of the nucleus. In addition, they are involved in the regulation of …
the structural properties of the nucleus. In addition, they are involved in the regulation of …
Orchestrating nuclear envelope disassembly and reassembly during mitosis
S Güttinger, E Laurell, U Kutay - Nature reviews Molecular cell biology, 2009 - nature.com
Cell division in eukaryotes requires extensive architectural changes of the nuclear envelope
(NE) to ensure that segregated DNA is finally enclosed in a single cell nucleus in each …
(NE) to ensure that segregated DNA is finally enclosed in a single cell nucleus in each …
The nuclear envelope
MW Hetzer - Cold Spring Harbor perspectives in biology, 2010 - cshperspectives.cshlp.org
The nuclear envelope (NE) is a highly regulated membrane barrier that separates the
nucleus from the cytoplasm in eukaryotic cells. It contains a large number of different …
nucleus from the cytoplasm in eukaryotic cells. It contains a large number of different …