Nuclear compartmentalization as a mechanism of quantitative control of gene expression

P Bhat, D Honson, M Guttman - Nature Reviews Molecular Cell Biology, 2021 - nature.com
Gene regulation requires the dynamic coordination of hundreds of regulatory factors at
precise genomic and RNA targets. Although many regulatory factors have specific affinity for …

Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate

MJ Dalby, N Gadegaard, ROC Oreffo - Nature materials, 2014 - nature.com
Stem cells respond to nanoscale surface features, with changes in cell growth and
differentiation mediated by alterations in cell adhesion. The interaction of nanotopographical …

Nuclear lamins: thin filaments with major functions

R de Leeuw, Y Gruenbaum, O Medalia - Trends in cell biology, 2018 - cell.com
The nuclear lamina is a nuclear peripheral meshwork that is mainly composed of nuclear
lamins, although a small fraction of lamins also localizes throughout the nucleoplasm …

Endoplasmic reticulum structure and interconnections with other organelles

AR English, GK Voeltz - Cold Spring Harbor perspectives …, 2013 - cshperspectives.cshlp.org
The endoplasmic reticulum (ER) is a large, continuous membrane-bound organelle
comprised of functionally and structurally distinct domains including the nuclear envelope …

LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins

BA Sosa, A Rothballer, U Kutay, TU Schwartz - Cell, 2012 - cell.com
Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the nuclear envelope
and are composed of KASH and SUN proteins residing in the outer and inner nuclear …

Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges

DA Starr, HN Fridolfsson - Annual review of cell and …, 2010 - annualreviews.org
The nuclear envelope links the cytoskeleton to structural components of the nucleus. It
functions to coordinate nuclear migration and anchorage, organize chromatin, and aid …

Intermediate filaments: from cell architecture to nanomechanics

H Herrmann, H Bär, L Kreplak, SV Strelkov… - … reviews Molecular cell …, 2007 - nature.com
Intermediate filaments (IFs) constitute a major structural element of animal cells. They build
two distinct systems, one in the nucleus and one in the cytoplasm. In both cases, their major …

Nuclear lamins

T Dechat, SA Adam, P Taimen… - Cold Spring …, 2010 - cshperspectives.cshlp.org
The nuclear lamins are type V intermediate filament proteins that are critically important for
the structural properties of the nucleus. In addition, they are involved in the regulation of …

Orchestrating nuclear envelope disassembly and reassembly during mitosis

S Güttinger, E Laurell, U Kutay - Nature reviews Molecular cell biology, 2009 - nature.com
Cell division in eukaryotes requires extensive architectural changes of the nuclear envelope
(NE) to ensure that segregated DNA is finally enclosed in a single cell nucleus in each …

The nuclear envelope

MW Hetzer - Cold Spring Harbor perspectives in biology, 2010 - cshperspectives.cshlp.org
The nuclear envelope (NE) is a highly regulated membrane barrier that separates the
nucleus from the cytoplasm in eukaryotic cells. It contains a large number of different …