Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin
B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse …

Ischemic stroke continues to be one of the most challenging diseases in translational
neurology. Tissue plasminogen activator (tPA) remains the only approved treatment for …

Cerebral ischemia/reperfusion (I/R) injury triggers multiple and distinct but overlapping cell
signaling pathways, which may lead to cell survival or cell damage. There is overwhelming …

Glucagon-like peptide-1 (GLP-1) is an incretin hormone known to stimulate glucose-
dependent insulin secretion. The GLP-1 receptor agonist, exendin-4, has similar properties …

Background and Purpose—White matter lesions contribute to cognitive impairment in
poststroke patients. The present study was designed to assess the neuroprotective …

The initiating mechanisms of migraine attacks are very complex but may involve the cyclic
AMP signalling pathway. It is unknown whether intracellular cyclic AMP accumulation …

A neuroprotective role of autophagy mediates the degradation of β-amyloid peptide (Aβ) in
Alzheimer's disease (AD). The previous study showed cilostazol modulates autophagy by …

Mitochondria have various roles in cellular metabolism and homeostasis. Because
mitochondrial dysfunction is associated with many acute and chronic degenerative …

BACKGROUND AND PURPOSE Cilostazol may be effective in dementia associated with a
cerebral ischaemia. In this study, we examined whether it exerts beneficial effects on …

Objective As stroke represents one of the leading causes of mortality and disability
worldwide, we aimed to determine the preventive effect of different antiplatelet therapies …