Glioblastoma (GB) is a primary malignancy of the central nervous system that is classified by
the WHO as a grade IV astrocytoma. Despite decades of research, several aspects about the …

Introduction Brain tumors are complex and heterogeneous malignancies with significant
challenges in diagnosis, prognosis, and therapy. Proteomics, the large-scale study of …

Background There is an urgent need to better understand the mechanisms associated with
the development, progression, and onset of recurrence after initial surgery in glioblastoma …

Oligodendrocyte precursor markers have become of great interest to identify new diagnostic
and therapeutic targets for diffuse gliomas, since state-of-the-art studies point towards …

Single-cell RNA-sequencing (scRNA-seq) is becoming a ubiquitous method in profiling the
cellular transcriptomes of both malignant and non-malignant cells from the human brain …

Background Given the lack of research on disulfidptosis, our study aimed to dissect its role in
pan-cancer and explore the crosstalk between disulfidptosis and cancer immunity. Methods …

This article presents some of the author's neuropathological highlights in the field on neuro-
oncology research encountered in 2022. Major advances were made in the development of …

Background: IDH-wildtype glioblastoma (GBM) is the most prevalent primary brain cancer
with a 5-year survival rate below 10%. Despite combined treatment through extensive …

To study the evolutionary processes that drive malignant progression of IDH-mutant
astrocytomas, we performed multi-omics on a large cohort of matched initial and recurrent …