Elevated rates of reactive oxygen species (ROS) have been detected in almost all cancers,
where they promote many aspects of tumour development and progression. However …

Recently, a consensus has emerged that cofilin severing activity can generate free actin
filament ends that are accessible for F-actin polymerization and depolymerization without …

Targeting organelles by modulating the redox potential of mitochondria is a promising
approach to kill cancer cells that minimizes acquired drug resistance. However, it lacks …

Cofilin and actin-depolymerizing factor (ADF) are actin-binding proteins that play an
essential role in regulating actin filament dynamics and reorganization by stimulating the …

Vascular injury triggers dedifferentiation and cytoskeletal remodeling of smooth muscle cells
(SMCs), culminating in vessel occlusion. Serum response factor (SRF) and its coactivator …

Recent findings have significantly expanded our understanding of the regulation of actin-
depolymerizing factor (ADF)/cofilin proteins and the profound multifaceted impact that these …

The plasma membrane and the underlying cortical actin cytoskeleton undergo continuous
dynamic interplay that is responsible for many essential aspects of cell physiology …

The 14-3-3 proteins were the first phosphoserine/phosphothreonine-binding proteins to be
discovered, a finding that provided the foundation for their prominent role in cell signaling …

Metastatic dissemination is often initiated by the reactivation of an embryonic development
program referred to as epithelial-mesenchymal transition (EMT). The transcription factor …

Recent observations related to the structure of the cytoskeleton in neurons and novel
cytoskeletal abnormalities involved in the pathophysiology of some neurological diseases …