The thioredoxin (Trx) system is one of the central antioxidant systems in mammalian cells,
maintaining a reducing environment by catalyzing electron flux from nicotinamide adenine …

Identification of thioredoxin binding protein-2 (TBP-2), which is currently known as
thioredoxin interacting protein (TXNIP), as an important binding partner for thioredoxin (TRX) …

Stearoyl-CoA desaturase (SCD) is expressed at high levels in several human tissues and is
required for the biosynthesis of oleate (18: 1) and palmitoleate (16: 1). These …

Recently, we identified thioredoxin-interacting protein (TXNIP) as the most dramatically
glucose-induced gene in our human islet microarray study. TXNIP is a regulator of the …

Pancreatic β-cells are responsible for insulin production, and loss of functional β-cell mass is
now recognized as a critical step in the pathogenesis of both type 1 and type 2 diabetes …

In the last few years, there has been increasing interest in the physiological role of acylation-
stimulating protein (ASP). Recent studies in rats and mice, in particular in C3 (−/−) mice that …

Geneticists have repeatedly turned to population isolates for mapping and cloning
Mendelian disease genes. Population isolates possess many advantages in this regard …

How ω-3 and ω-6 polyunsaturated fatty acids (PUFAs) lower plasma lipid levels is
incompletely understood. We previously showed that marine ω-3 PUFAs (docosahexaenoic …

Significance: The thioredoxin-interacting protein (TXNIP, also termed VDUP1 for vitamin D
upregulated protein or TBP2 for thioredoxin-binding protein) was originally discovered by …

Traditional risk factors for coronary artery disease (CAD) predict about 50% of the risk of
developing CAD. The Adult Treatment Panel (ATP) III has defined emerging risk factors for …