The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …

Diagnosing pulmonary sarcoidosis raises challenges due to both the absence of a specific
diagnostic criterion and the varied presentations capable of mimicking many other …

The inability to effectively model sarcoidosis in the laboratory or in animals continues to
hinder the discovery and translation of new, targeted treatments. The granuloma is the …

Sarcoidosis is a complex systemic disease. Our study aimed to (1) identify novel alleles
associated with sarcoidosis susceptibility;(2) provide an in-depth evaluation of HLA alleles …

Pulmonary involvement occurs in up to 95% of sarcoidosis cases. In this pilot study, we
examine lung compartment-specific protein expression to identify pathways linked to …

Introduction: Sarcoidosis is a systemic disease of unknown etiology characterized by the
development of non-caseating epitheloid granulomas. The lungs are the most commonly …

Rationale: A subpopulation of B cells (age-associated B cells [ABCs]) is increased in mice
and humans with infections or autoimmune diseases. Because depletion of these cells might …

Non-infectious inflammatory cutaneous granulomatous diseases including granuloma
annulare (GA), cutaneous sarcoidosis (CS), and necrobiosis lipoidica (NL) are diverse …

Rare respiratory diseases are ready for primetime: from Rare Disease Day to the European
Reference Networks | European Respiratory Society Skip to main content Main menu Home …

Epigenetic marks are likely to explain variability of response to antigen in granulomatous
lung disease. The objective of this study was to identify DNA methylation and gene …