Gene polymorphisms and prognosis of head and neck squamous cell carcinoma: A systematic review

M Rajabi-Moghaddam… - Reports of Practical …, 2022 - journals.viamedica.pl
Background: Head and neck squamous cell carcinomas (HNSCCs) are associated with
variable prognosis even with similar clinical characteristics and treatments. Gene …

CYP2A6 associates with respiratory disease risk and younger age of diagnosis: a phenome-wide association Mendelian Randomization study

H Giratallah, MJ Chenoweth, JG Pouget… - Human Molecular …, 2024 - academic.oup.com
CYP2A6, a genetically variable enzyme, inactivates nicotine, activates carcinogens, and
metabolizes many pharmaceuticals. Variation in CYP2A6 influences smoking behaviors and …

Genotyping, characterization, and imputation of known and novel CYP2A6 structural variants using SNP array data

AWR Langlois, A El-Boraie, JG Pouget… - Journal of Human …, 2023 - nature.com
CYP2A6 metabolically inactivates nicotine. Faster CYP2A6 activity is associated with
heavier smoking and higher lung cancer risk. The CYP2A6 gene is polymorphic, including …

Alterations in pharmacogenetic genes and their implications for imatinib resistance in Chronic Myeloid Leukemia patients from an admixed population

KBC Cereja-Pantoja, TC de Brito Azevedo… - Cancer Chemotherapy …, 2024 - Springer
Imatinib is the tyrosine kinase inhibitor used as the gold standard for the treatment of
Chronic Myeloid Leukemia. However, about 30% of patients do not respond well to this …

Impact of single nucleotide polymorphisms and cigarette smoking on cancer risk and survival of patients with head and neck squamous cell carcinoma

BÅ Andersson, M Nilsson, D Oliva - Biomarkers, 2022 - Taylor & Francis
Background: Head and neck squamous cell carcinoma (HNSCC) is a disease involving
genetic and lifestyle risk factors such as smoking or high-risk papillomavirus (HR-HPV) …