Improving lung health in low-income and middle-income countries: from challenges to solutions

J Meghji, K Mortimer, A Agusti, BW Allwood, I Asher… - The Lancet, 2021 - thelancet.com
Low-income and middle-income countries (LMICs) bear a disproportionately high burden of
the global morbidity and mortality caused by chronic respiratory diseases (CRDs), including …

Bronchiectasis—a clinical review

AE O'Donnell - New England Journal of Medicine, 2022 - Mass Medical Soc
Bronchiectasis — A Clinical Review | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

[HTML][HTML] Bronchiectasis in Europe: data on disease characteristics from the European Bronchiectasis registry (EMBARC)

JD Chalmers, E Polverino, ML Crichton… - The Lancet …, 2023 - thelancet.com
Background Bronchiectasis is a heterogeneous, neglected disease with few multicentre
studies exploring the causes, severity, microbiology, and treatment of the disease across …

[HTML][HTML] British Thoracic Society Guideline for bronchiectasis in adults

AT Hill, AL Sullivan, JD Chalmers, A De Soyza… - Thorax, 2019 - thorax.bmj.com
CT scanning can also aid in identifying an aetiology of bronchiectasis eg Allergic
bronchopulmonary aspergillosis (ABPA), Non-tuberculous mycobacteria (NTM), primary …

European Respiratory Society guidelines for the management of adult bronchiectasis

E Polverino, PC Goeminne… - European …, 2017 - Eur Respiratory Soc
Bronchiectasis in adults is a chronic disorder associated with poor quality of life and frequent
exacerbations in many patients. There have been no previous international guidelines. The …

European Respiratory Society guidelines for the management of children and adolescents with bronchiectasis

AB Chang, R Fortescue, K Grimwood… - European …, 2021 - Eur Respiratory Soc
There is increasing awareness of bronchiectasis in children and adolescents, a chronic
pulmonary disorder associated with poor quality of life for the child/adolescent and their …

[HTML][HTML] The lung microbiome during health and disease

K Yagi, GB Huffnagle, NW Lukacs, N Asai - International journal of …, 2021 - mdpi.com
Healthy human lungs have traditionally been considered to be a sterile organ. However,
culture-independent molecular techniques have reported that large numbers of microbes …

Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity

PA Flume, JD Chalmers, KN Olivier - The Lancet, 2018 - thelancet.com
Bronchiectasis is characterised by pathological dilation of the airways. More specifically, the
radiographic demonstration of airway enlargement is the common feature of a …

Neutrophil extracellular traps, disease severity, and antibiotic response in bronchiectasis: an international, observational, multicohort study

HR Keir, A Shoemark, AJ Dicker, L Perea… - The lancet Respiratory …, 2021 - thelancet.com
Background Bronchiectasis is predominantly a neutrophilic inflammatory disease. There are
no established therapies that directly target neutrophilic inflammation because little is …

Bronchiectasis

JD Chalmers, AB Chang, SH Chotirmall… - Nature reviews Disease …, 2018 - nature.com
Bronchiectasis refers to abnormal dilatation of the bronchi. Airway dilatation can lead to
failure of mucus clearance and increased risk of infection. Pathophysiological mechanisms …