Ketones as strategic building blocks for the synthesis of natural product-inspired compounds

DJ Foley, H Waldmann - Chemical Society Reviews, 2022 - pubs.rsc.org
Natural product-inspired compound collections serve as excellent sources for the
identification of new bioactive compounds to treat disease. However, such compounds must …

Ten Years of Glory in the α-Functionalizations of Acetophenones: Progress Through Kornblum Oxidation and C–H Functionalization

B Deka, GK Rastogi, ML Deb, PK Baruah - Topics in Current Chemistry, 2022 - Springer
This review article focuses on the α-functionalization of acetophenones involving Kornblum
oxidation and C–H functionalizations. Although various other strategies, such as classical …

Manganese‐catalyzed hydrofunctionalization of alkenes

JR Carney, BR Dillon, L Campbell… - Angewandte Chemie …, 2018 - Wiley Online Library
The manganese‐catalyzed hydrosilylation and hydroboration of alkenes has been
developed using a single manganese (II) precatalyst and reaction protocol. Both reactions …

Synthesis of isoquinolines via visible light-promoted insertion of vinyl isocyanides with diaryliodonium salts

H Jiang, Y Cheng, R Wang, Y Zhang… - Chemical Communications, 2014 - pubs.rsc.org
A synthetic strategy for multi-substituted isoquinoline derivatives has been developed using
visible light-promoted vinyl isocyanide insertion with diaryliodonium salts at room …

Asymmetric Transfer Hydrogenation of (Hetero)arylketones with Tethered Rh(III)–N-(p-Tolylsulfonyl)-1,2-diphenylethylene-1,2-diamine Complexes: Scope and …

LS Zheng, Q Llopis, PG Echeverria… - The Journal of …, 2017 - ACS Publications
A series of new tethered Rh (III)/Cp* complexes containing the N-(p-tolylsulfonyl)-1, 2-
diphenylethylene-1, 2-diamine ligand have been prepared, characterized, and evaluated in …

Copper-catalyzed aerobic synthesis of 2-arylpyridines from acetophenones and 1, 3-diaminopropane

LY Xi, RY Zhang, S Liang, SY Chen, XQ Yu - Organic letters, 2014 - ACS Publications
Copper-Catalyzed Aerobic Synthesis of 2-Arylpyridines from Acetophenones and 1,3-Diaminopropane
| Organic Letters ACS ACS Publications C&EN CAS Find my institution Log In Organic Letters …

Short and Efficient Syntheses of Protoberberine Alkaloids using Palladium‐Catalyzed Enolate Arylation

AE Gatland, BS Pilgrim, PA Procopiou… - Angewandte Chemie …, 2014 - Wiley Online Library
A concise synthesis of the biologically active alkaloid berberine is reported, and a versatile
palladium‐catalyzed enolate arylation is used to form the isoquinoline core. The overall …

A unified strategy for the syntheses of the isoquinolinium alkaloids berberine, coptisine, and jatrorrhizine

LM Mori-Quiroz, SL Hedrick, AR De Los Santos… - Organic …, 2018 - ACS Publications
Total syntheses of the antibacterial alkaloids berberine, coptisine, and jatrorrhizine have
been achieved in four steps through a unified route. The key step of this strategy is an …

A room-temperature protocol to access isoquinolines through Ag (I) catalysed annulation of o-(1-alkynyl) arylaldehydes and ketones with NH 4 OAc: Elaboration to …

V Reddy, AS Jadhav, RV Anand - Organic & Biomolecular Chemistry, 2015 - pubs.rsc.org
An efficient and mild protocol for the direct construction of aryl-and alkyl-substituted
isoquinolines has been realized through silver nitrate catalyzed aromatic annulation of o-(1 …

Palladium-catalyzed enolate arylation as a key C–C bond-forming reaction for the synthesis of isoquinolines

BS Pilgrim, AE Gatland, CHA Esteves… - Organic & …, 2016 - pubs.rsc.org
The palladium-catalyzed coupling of an enolate with an ortho-functionalized aryl halide (an
α-arylation) furnishes a protected 1, 5-dicarbonyl moiety that can be cyclized to an …