Schizophrenia is a psychotic disorder characterized by delusions, hallucinations, negative
symptoms, as well as behavioral and cognitive dysfunction. It is a pathoetiologically …

Structural and functional integrity of the cerebral vasculature ensures proper brain
development and function, as well as healthy aging. The inability of the brain to store energy …

AKT is a kinase regulating numerous cellular processes in the brain, and mutations in AKT
are known to affect brain function. AKT is indirectly implicated in synaptic plasticity, but its …

Background Betaine is known to act against various biological stresses and its levels were
reported to be decreased in schizophrenia patients. We aimed to test the role of betaine in …

Schizophrenia is a neurodevelopmental disease characterized by cerebral connectivity
impairment and loss of gray matter. It was described in adult schizophrenia patients (SZP) …

We are studying the molecular pathology of a sub-group within schizophrenia (∼ 25%:
termed Muscarinic Receptor Deficit subgroup of Schizophrenia (MRDS)) who can be …

Schizophrenia pathogenesis remains challenging to define; however, there is strong
evidence that the interaction of genetic and environmental factors causes the disorder. This …

The mechanistic target of rapamycin (also known as mammalian target of
rapamycin)(mTOR)-dependent signaling pathway plays an important role in protein …

Protein kinase-B (Akt) and the mechanistic target of rapamycin (mTOR) signaling pathways
are implicated in Alzheimer's disease (AD) pathology. Akt/mTOR signaling pathways …

Phosphoinositides (PIs) play important roles in the structure and function of the brain.
Associations between PIs and the pathophysiology of schizophrenia have been studied …