[HTML][HTML] Tumor Necrosis Factor-Alpha Modulates Expression of Genes Involved in Cytokines and Chemokine Pathways in Proliferative Myoblast Cells

AM Alvarez, CEM Trufen, MV Buri, MBN de Sousa… - Cells, 2024 - mdpi.com
Skeletal muscle regeneration after injury is a complex process involving inflammatory
signaling and myoblast activation. Pro-inflammatory cytokines like tumor necrosis factor …

Effects of inhibition of 5-lipoxygenase and 12-lipoxygenase pathways on skeletal muscle fiber regeneration

MV Damico, CD Gil, RO Godinho, ESA Pacini… - Chemico-Biological …, 2023 - Elsevier
We investigated the effect of inhibition of 5-lipoxigenase (LOX) and 12-LOX pathways on the
regeneration of skeletal muscle fibers after injury induced by a myotoxin (MTX) …

Fraction of C. d. collilineatus venom containing crotapotin protects PC12 cells against MPP + toxicity by activating the NGF-signaling pathway

CP Bernardes, E Lopes Pinheiro, IG Ferreira… - Journal of Venomous …, 2024 - SciELO Brasil
Background: Parkinson's disease (PD) is the second most prevalent neurodegenerative
disease. There is no effective treatment for neurodegenerative diseases. Snake venoms are …

Mapping possible interaction sites for crotoxin in CNF, a gamma PLA2 inhibitor from Crotalus durissus terrificus rattle snake, using SPOT synthesis

PC Campos, HC de Oliveira, PL Ortolani, LA de Melo… - Toxicon, 2023 - Elsevier
Abstract Phospholipases A 2 (PLA 2 s) are main components of snake venoms. Several
snake species possess endogenous PLA 2 inhibitors in their circulating blood, which are …

The early inhibition of the COX-2 pathway in viperid phospholipase A2-induced skeletal muscle myotoxicity accelerates the tissue regeneration

ACS Zuntini, MV Damico, CD Gil, RO Godinho… - Toxicology and Applied …, 2023 - Elsevier
The administration of non-steroidal anti-inflammatory drugs in the treatment of injury and
muscle regeneration is still contradictory in effectiveness, especially regarding the timing of …

Losac and Lopap Recombinant Proteins from Lonomia obliqua Bristles Positively Modulate the Myoblast Proliferation Process

AM Alvarez, MP Alvarez-Flores… - Frontiers in Molecular …, 2022 - frontiersin.org
The pursuit of better therapies for disorders creating deficiencies in skeletal muscle
regeneration is in progress, and several biotoxins are used in skeletal muscle research …