Cytochromes P450 associated with the biosyntheses of ribosomally synthesized and post-translationally modified peptides

G Zhong - ACS bio & med Chem Au, 2023 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a class of
exponentially increased natural products with characteristic chemical structures, topologies …

Proteases involved in leader peptide removal during RiPP biosynthesis

SM Eslami, WA van der Donk - ACS Bio & Med Chem Au, 2023 - ACS Publications
Ribosomally synthesized and post-translationally modified peptides (RiPPs) have received
much attention in recent years because of their promising bioactivities and the portability of …

RefSeq and the prokaryotic genome annotation pipeline in the age of metagenomes

DH Haft, A Badretdin, G Coulouris… - Nucleic Acids …, 2024 - academic.oup.com
Abstract The Reference Sequence (RefSeq) project at the National Center for Biotechnology
Information (NCBI) contains over 315 000 bacterial and archaeal genomes and 236 million …

Bacterial Cytochrome P450 Catalyzed Post‐translational Macrocyclization of Ribosomal Peptides

BB He, J Liu, Z Cheng, R Liu, Z Zhong… - Angewandte Chemie …, 2023 - Wiley Online Library
Ribosomally synthesized and post‐translationally modified peptides (RiPPs) are a
fascinating group of natural products that exhibit diverse structural features and bioactivities …

Core-dependent post-translational modifications guide the biosynthesis of a new class of hypermodified peptides

ZF Pei, L Zhu, SK Nair - Nature communications, 2023 - nature.com
The ribosomally synthesized and post-translationally modified peptide (RiPPs) class of
natural products has undergone significant expansion due to the rapid growth in genome …

Biosynthesis of macrocyclic peptides with C-terminal β-amino-α-keto acid groups by three different metalloenzymes

DT Nguyen, L Zhu, DL Gray, TJ Woods… - ACS Central …, 2024 - ACS Publications
Advances in genome sequencing and bioinformatics methods have identified a myriad of
biosynthetic gene clusters (BGCs) encoding uncharacterized molecules. By mining …

Discovery and engineering of ribosomally synthesized and post-translationally modified peptide (RiPP) natural products

H Li, W Ding, Q Zhang - RSC Chemical Biology, 2024 - pubs.rsc.org
Ribosomally synthesized and post-translationally modified peptides (RiPPs) represent a
diverse superfamily of natural products with immense potential for drug development. This …

A review on the diversity of antimicrobial peptides and genome mining strategies for their prediction

N Kumar, P Bhagwat, S Singh, S Pillai - Biochimie, 2024 - Elsevier
Antibiotic resistance has become one of the most serious threats to human health in recent
years. In response to the increasing microbial resistance to the antibiotics currently …

[HTML][HTML] Unravelling the secondary metabolome and biocontrol potential of the recently described species Bacillus nakamurai

F Nimbeshaho, G Nihorimbere, AA Arias… - Microbiological …, 2024 - Elsevier
In the prospect of novel potential biocontrol agents, a new strain BDI-IS1 belonging to the
recently described Bacillus nakamurai was selected for its strong in vitro antimicrobial …

Illuminating Substrate Preferences of Promiscuous F420H2-Dependent Dehydroamino Acid Reductases with 4-Track mRNA Display

AA Vinogradov, G Bashiri, H Suga - Journal of the American …, 2024 - ACS Publications
Stereoselective reduction of dehydroamino acids is a common biosynthetic strategy to
introduce d-amino acids into peptidic natural products. The reduction, often observed during …