Lon proteases, members of the AAA+ superfamily of enzymes, are key components of the
protein quality control system in bacterial cells, as well as in the mitochondria and other …

Hsp70 interactions are critical for cellular viability and the response to stress. Previous
attempts to characterize Hsp70 interactions have been limited by their transient nature and …

The soil enzymes are the heart of the biochemical reactions that occur in the soil saving the
soil nutrients needed for plant growth. Recently yeast's importance as plant growth …

Many AAA+ (ATPases associated with diverse cellular activities) proteins function as protein
or DNA remodelers by threading the substrate through the central pore of their hexameric …

While all eukaryotic cells are dependent on mitochondria for function, in a complex tissue,
which cell type and which cell behavior are more sensitive to mitochondrial deficiency …

Mitochondria consist of hundreds of proteins, most of which are inaccessible to the
proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial …

AAA+ enzymes use energy from ATP hydrolysis to remodel diverse cellular targets.
Structures of substrate-bound AAA+ complexes suggest that these enzymes employ a …

Aside from its role as the universal energy source of the cell, mitochondria also control many
aspects of cell behavior. In an intact tissue, whether all cells require mitochondria function to …

To ensure correct protein function, the cells are equipped with a tightly regulated network of
chaperones that support protein folding and actively participate in protein quality control …

Mitochondrial AAA proteases are responsible for protein quality control within the organelle.
Generally, they dispose of misfolded, damaged, unassembled or superfluous proteins …