Drug-induced cardiotoxicity not only leads to the attrition of drugs during development, but
also contributes to the high morbidity and mortality rates of cardiovascular diseases …

Several neonicotinoids have recently been shown to activate the nicotinic acetylcholine
receptor (nAChR) on human neurons. Moreover, imidacloprid (IMI) and other members of …

Read-across (RAx) translates available information from well-characterized chemicals to a
substance for which there is a toxicological data gap. The OECD is working on case studies …

Neonicotinoid pesticides, originally developed to target the insect nervous system, have
been reported to interact with human receptors and to activate rodent neurons. Therefore …

Abstract In 2016, the European Commission launched the EU-ToxRisk research project to
develop and promote animal-free approaches in toxicology. The 36 partners of this …

Evidence is mounting for the central role of mitochondrial dysfunction in several pathologies
including metabolic diseases, accelerated ageing, neurodegenerative diseases and in …

Inhibition of complex I of the mitochondrial respiratory chain (cI) by rotenone and methyl-
phenylpyridinium (MPP+) leads to the degeneration of dopaminergic neurons in man and …

The causes of nigrostriatal cell death in idiopathic Parkinson's disease are unknown, but
exposure to toxic chemicals may play some role. We followed up here on suggestions that …

Only few cell-based test methods are described by Organisation for Economic Co-operation
and Development (OECD) test guidelines or other regulatory references (eg, the European …

Early life exposure to environmental chemicals can cause developmental neurotoxicity
(DNT). The impairment of key neurodevelopmental processes such as neurite outgrowth …