APOE4 and age affect the brain entorhinal cortex structure and blood arachidonic acid and docosahexaenoic acid levels after mild TBI

G Aldrich, JE Evans, R Davis, L Jurin, S Oberlin… - Scientific Reports, 2024 - nature.com
A reduction in the thickness and volume of the brain entorhinal cortex (EC), together with
changes in blood arachidonic acid (AA) and docosahexaenoic acid (DHA), are associated …

Proteome profiling of cerebrospinal fluid using machine learning shows a unique protein signature associated with APOE4 genotype

A Shvetcov, S Thomson, AN Cho, HM Wilkins… - Aging …, 2024 - Wiley Online Library
Proteome changes associated with APOE4 variant carriage that are independent of
Alzheimer's disease (AD) pathology and diagnosis are unknown. This study investigated …

Cerebrospinal fluid proteome profiling using machine learning shows a unique protein signature associated with APOE4 genotype

A Shvetcov, S Thomson, AN Cho, HM Wilkins, JH Reed… - bioRxiv, 2024 - biorxiv.org
APOE4 is the biggest genetic risk factor for Alzheimers disease (AD). Proteome-wide
changes independent of AD brain pathology and whether these extend to APOE4 carriers …

APOE 𝜀4‐related blood–brain barrier breakdown is associated with microstructural abnormalities

ET Reas, SK Solders, A Tsiknia… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION Blood–brain barrier (BBB) dysfunction occurs in Alzheimer's disease (AD).
Yet, the stage at which it appears along the AD time course and whether it contributes to …

APOE

ET Reas, SK Solders, A Tsiknia, C Triebswetter… - 2024 - escholarship.org
IntroductionBlood-brain barrier (BBB) dysfunction occurs in Alzheimer's disease (AD). Yet,
the stage at which it appears along the AD time course and whether it contributes to …