Major depression is a devastating disease affecting an increasing number of people from a
young age worldwide, a situation that is expected to be worsened by the COVID-19 …

Drug abuse is a major global health and economic problem. However, there are no
pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse …

Background Diabetic polyneuropathy (DPN) is the most common and early developing
complication of diabetes mellitus, and the key contributor for foot ulcers development, with …

Intensive studies on stem cell therapy reveal that benefits of stem cells attribute to the
paracrine effects. Hence, direct delivery of stem cell secretome to the injured site shows the …

Due to their characteristics, mesenchymal stem cells (MSCs) are considered a potential
therapy for brain tissue injury or degeneration. Nevertheless, despite the promising results …

Drug-induced liver injury (DILI) is one of the leading causes of acute liver injury. While many
factors may contribute to the susceptibility to DILI, obese patients with hepatic steatosis are …

Perinatal Asphyxia (PA) is a leading cause of motor and neuropsychiatric disability
associated with sustained oxidative stress, neuroinflammation, and cell death, affecting …

Treatment of central nervous system (CNS) disorders is challenging using conventional
delivery strategies and routes of administration because of the presence of the blood–brain …

The present study investigates the possible therapeutic effects of human mesenchymal stem
cell-derived secretome on morphine dependence and relapse. This was studied in a new …

Chronic opioid intake leads to several brain changes involved in the development of
dependence, whereby an early hedonistic effect (liking) extends to the need to self …