Using singlet oxygen to synthesize natural products and drugs
AA Ghogare, A Greer - Chemical reviews, 2016 - ACS Publications
This Review describes singlet oxygen (1O2) in the organic synthesis of targets on possible
1O2 biosynthetic routes. The visible-light sensitized production of 1O2 is not only useful for …
1O2 biosynthetic routes. The visible-light sensitized production of 1O2 is not only useful for …
Natural withanolides, an update
G Xia, S Cao, L Chen, F Qiu - Natural Product Reports, 2022 - pubs.rsc.org
Covering: March 2010 to December 2020. Previous review: Nat. Prod. Rep., 2011, 28, 705
This review summarizes the latest progress and perspectives on the structural classification …
This review summarizes the latest progress and perspectives on the structural classification …
Neurotrophic natural products: chemistry and biology
J Xu, MH Lacoske… - Angewandte Chemie …, 2014 - Wiley Online Library
Neurodegenerative diseases and spinal cord injury affect approximately 50 million people
worldwide, bringing the total healthcare cost to over 600 billion dollars per year. Nervous …
worldwide, bringing the total healthcare cost to over 600 billion dollars per year. Nervous …
[HTML][HTML] Major biochemical constituents of Withania somnifera (ashwagandha) extract: A review of chemical analysis
MT Abdelwahed, MA Hegazy… - Reviews in Analytical …, 2023 - degruyter.com
Ashwagandha (Withania somnifera) is a very popular medicinal herb originated mainly in
India and found in the Middle East and parts of Africa. Ashwagandha has gained recognition …
India and found in the Middle East and parts of Africa. Ashwagandha has gained recognition …
Biology‐Oriented Synthesis of a Withanolide‐Inspired Compound Collection Reveals Novel Modulators of Hedgehog Signaling
J Švenda, M Sheremet, L Kremer, L Maier… - Angewandte …, 2015 - Wiley Online Library
Biology‐oriented synthesis employs the structural information encoded in complex natural
products to guide the synthesis of compound collections enriched in bioactivity. The trans …
products to guide the synthesis of compound collections enriched in bioactivity. The trans …
Photocatalytic Reductive Radical‐Polar Crossover for a Base‐Free Corey–Seebach Reaction
K Donabauer, K Murugesan, U Rozman… - … A European Journal, 2020 - Wiley Online Library
A metal‐free generation of carbanion nucleophiles is of prime importance in organic
synthesis. Herein we report a photocatalytic approach to the Corey–Seebach reaction. The …
synthesis. Herein we report a photocatalytic approach to the Corey–Seebach reaction. The …
Contemporary advancements in the semi-synthesis of bioactive terpenoids and steroids
Z Wang, C Hui - Organic & Biomolecular Chemistry, 2021 - pubs.rsc.org
Many natural products have intriguing biological properties that arise from their fascinating
chemical structures. However, the intrinsic complexity of the structural skeleton and the …
chemical structures. However, the intrinsic complexity of the structural skeleton and the …
[HTML][HTML] The Corey-Seebach reagent in the 21st century: A Review
The Corey-Seebach reagent plays an important role in organic synthesis because of its
broad synthetic applications. The Corey-Seebach reagent is formed by the reaction of an …
broad synthetic applications. The Corey-Seebach reagent is formed by the reaction of an …
[HTML][HTML] Antiproliferation potential of withaferin A on human osteosarcoma cells via the inhibition of G2/M checkpoint proteins
TZ Lv, GS Wang - Experimental and therapeutic …, 2015 - spandidos-publications.com
Withaferin A (WA) is a well-known steroidal lactone of the medicinally important plant,
Withania somnifera. This secondary metabolite has been noted for its anticancer effects …
Withania somnifera. This secondary metabolite has been noted for its anticancer effects …
Total synthesis of the alleged structure of (+)-fimbricalyxoid A
LP Li, JQ Han, F Yang, X Wu, JH Xie, QL Zhou - Organic Letters, 2022 - ACS Publications
An enantioselective total synthesis of the alleged structure of (+)-fimbricalyxoid A is reported.
The synthetic strategy features a pyridine-N-oxidate-mediated SN2′ reaction to introduce …
The synthetic strategy features a pyridine-N-oxidate-mediated SN2′ reaction to introduce …