Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

Familial gastric cancer comprises at least three major syndromes: hereditary diffuse gastric
cancer, gastric adenocarcinoma and proximal polyposis of the stomach, and familial …

Importance E-cadherin (CDH1) is a cancer predisposition gene mutated in families meeting
clinically defined hereditary diffuse gastric cancer (HDGC). Reliable estimates of cancer risk …

Gastric cancer remains one of the deadly diseases with poor prognosis. New classification
of gastric cancers based on histologic features, genotypes and molecular phenotypes helps …

Gastric cancer remains highly prevalent and accounts for a notable proportion of global
cancer mortality. This cancer is also associated with poor survival rates. Understanding the …

While the incidence of gastric cancer has decreased worldwide in recent decades, the
incidence of signet-ring cell carcinoma (SRCC) is rising. SRCC has a specific epidemiology …

Tumour metastasis is the main cause of cancer related deaths. Metastasis is an intricate
multi-step process that requires the acquisition of several cancer cell features, including the …

25–30% of families fulfilling the criteria for hereditary diffuse gastric cancer have germline
mutations of the CDH1 (E-cadherin) gene. In light of new data and advancement of …

Germline CDH1 mutations confer a high lifetime risk of developing diffuse gastric (DGC) and
lobular breast cancer (LBC). A multidisciplinary workshop was organised to discuss genetic …

Introduction Germline mutation in CDH1 (E-cadherin) tumor suppressor gene is associated
with hereditary diffuse gastric cancer (HDGC) and lobular breast cancers (LBC). E-Cadherin …