To coordinate, adapt and respond to biological signals, cells convey specific messages to
other cells. An important aspect of cell–cell communication involves secretion of molecules …

A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …

Exosomes are nano-sized vesicles that serve as mediators for cell-to-cell communication.
With their unique nucleic acids, proteins, and lipids cargo compositions that reflect the …

Heterochronic blood exchange (HBE) has demonstrated that circulating factors restore
youthful features to aged tissues. However, the systemic mediators of those rejuvenating …

Extracellular vesicles (EVs) are important players for intercellular communication. EVs are
secreted by almost all cell types; they can transfer information between nearby or distant …

Osteoporosis and sarcopenia are two age-related diseases that affect the quality of life in the
elderly. Initially, they were thought to be two independent diseases; however, recently …

Recent investigations into heterochronic parabiosis have unveiled robust rejuvenating
effects of young blood on aged tissues. However, the specific rejuvenating mechanisms …

Cellular senescence, first observed and defined through cell culture studies, is a cell fate
associated with essentially permanent cell cycle arrest and that can be triggered by a variety …

Moment-to-moment adjustment of regional cerebral blood flow to neuronal activity via
neurovascular coupling (NVC or “functional hyperemia”) has a critical role in maintenance of …

According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …