Procalcitonin increase is associated with the development of critical care-acquired infections in COVID-19 ARDS

O Richards, P Pallmann, C King, Y Cheema, C Killick… - Antibiotics, 2021 - mdpi.com
Secondary bacterial infection in COVID-19 patients is associated with increased mortality
and disproportionately affects critically ill patients. This single-centre retrospective …

COVID-19 mixed impact on hospital antimicrobial stewardship activities: a qualitative study in UK-based hospitals

S Khan, SE Bond, M Bakhit, SS Hasan, AA Sadeq… - Antibiotics, 2022 - mdpi.com
Antimicrobial resistance (AMR) is a well-known global threat due to the subsequent increase
in antimicrobial usage. Several antimicrobial stewardship (AMS) strategies have been …

Procalcitonin to guide antibacterial prescribing in patients hospitalised with COVID-19

S Hughes, N Mughal, LSP Moore - Antibiotics, 2021 - mdpi.com
Antibacterial prescribing in patients presenting with COVID-19 remains discordant to rates of
bacterial co-infection. Implementing diagnostic tests to exclude bacterial infection may aid …

Impact of introducing procalcitonin testing on antibiotic usage in acute NHS hospitals during the first wave of COVID-19 in the UK: a controlled interrupted time series …

MJ Llewelyn, D Grozeva, P Howard… - Journal of …, 2022 - academic.oup.com
Background Blood biomarkers have the potential to help identify COVID-19 patients with
bacterial coinfection in whom antibiotics are indicated. During the COVID-19 pandemic …

Procalcitonin values fail to track the presence of secondary bacterial infections in COVID-19 ICU patients

E Harte, S Kumarasamysarma, B Phillips, O Mackay… - Antibiotics, 2023 - mdpi.com
The development of secondary bacterial infections in COVID-19 patients has been
associated with increased mortality and worse clinical outcomes. Consequently, many …

Procalcitonin is not a reliable biomarker of bacterial coinfection in people with coronavirus disease 2019 undergoing microbiological investigation at the time of …

KA Relph, CD Russell, CJ Fairfield… - Open forum …, 2022 - academic.oup.com
Admission procalcitonin measurements and microbiology results were available for 1040
hospitalized adults with coronavirus disease 2019 (from 48 902 included in the International …

The Association between Admission Procalcitonin Level and The Severity of COVID-19 Pneumonia: A Retrospective Cohort Study

M Aon, A Alsaeedi, A Alzafiri, MM Ibrahim… - Medicina, 2022 - mdpi.com
Background and Objectives: An elevated procalcitonin level has classically been linked to
bacterial infections. Data on the association between elevated procalcitonin and the …

Differences in inflammatory marker kinetics between the first and second wave of COVID-19 patients admitted to the ICU: a retrospective, single-center study

T Szakmany, W Tuckwell, E Harte, N Wetherall… - Journal of clinical …, 2021 - mdpi.com
Background: We sought to determine if there was a difference in the longitudinal
inflammatory response measured by white blood cell count (WBC), C-reactive protein …

C-reactive protein-guided use of procalcitonin in COVID-19

R Houghton, N Moore, R Williams… - JAC-antimicrobial …, 2021 - academic.oup.com
Background A low procalcitonin (PCT) concentration facilitates exclusion of bacterial co-
infections in COVID-19, but high costs associated with PCT measurements preclude …

Hematological Parameters and Procalcitonin as Discriminants between Bacterial Pneumonia-Induced Sepsis and Viral Sepsis Secondary to COVID-19: A …

E Moisa, M Dutu, D Corneci, IM Grintescu… - International Journal of …, 2023 - mdpi.com
Bacterial and viral sepsis induce alterations of all hematological parameters and
procalcitonin is used as a biomarker of infection and disease severity. Our aim was to study …