Depressive disorders are among the leading causes of global disease burden, but there has
been limited progress in understanding the causes of and treatments for these disorders. In …

Abstract Treatment-resistant depression (TRD) is a subset of Major Depressive Disorder
which does not respond to traditional and first-line therapeutic options. There are several …

Research on the adverse effects of mindfulness-based programs (MBPs) has been sparse
and hindered by methodological imprecision. The 44-item Meditation Experiences Interview …

Objective To confirm the rapid onset anti-suicidal benefits of ketamine in the short term and
at six weeks, overall and according to diagnostic group. Design Prospective, double blind …

Network approaches to psychometric constructs, in which constructs are modeled in terms of
interactions between their constituent factors, have rapidly gained popularity in psychology …

Depression is widely acknowledged to be a heterogeneous entity, and the need to further
characterize the individual patient who has received this diagnosis in order to personalize …

With the acceleration of the pace of work and life, people are facing more and more
pressure, which increases the probability of suffering from depression. However, many …

Objective Prevalence rates of depression and anxiety in patients with Multiple Sclerosis
(MS) vary widely across studies. Aim of this systematic review and meta-analysis was to a) …

Importance Approximately one-third of patients with major depressive disorder (MDD) do not
respond to available antidepressants. Objective To assess the efficacy, safety, and dose …

The format of the original Hamilton Rating Scale for Depression (HAM-D) was unstructured:
only general instructions were provided for rating individual items. Over the years, a number …