DNA is the central storage molecule of genetic information in the cell, and reading that
information is a central problem in biology. While sequencing technology has made …

This Review addresses methods for obtaining sequence information directly from
unamplified genomic length DNA. Our generic starting point is a large piece of DNA that …

Optical DNA mapping has over the last decade emerged as a very powerful tool for
obtaining long range sequence information from single DNA molecules. In optical DNA …

The human genome contains multiple layers of information that extend beyond the genetic
sequence. In fact, identical genetics do not necessarily yield identical phenotypes as evident …

Next generation sequencing (NGS) is revolutionizing all fields of biological research but it
fails to extract the full range of information associated with genetic material. Optical mapping …

Methyltransferases (MTases) form a large family of enzymes that methylate a diverse set of
targets, ranging from the three major biopolymers to small molecules. Most of these MTases …

Field-effect-transistor (FET) based electrical signal transduction is an increasingly prevalent
strategy for bio-sensing. This technique, often termed “Bio-FETs”, provides an essentially …

DNA confined to nanofluidic channels with a cross-section from tens to hundreds of nm wide
and hundreds of microns long stretches in an equilibrium process free of flow or end …

Deoxyribonucleic acid (DNA) is the blueprint on which life is based and transmitted, but the
way in which chromatin—a dynamic complex of nucleic acids and proteins—is packaged …

Miniaturized lab-on-a-chip (LOC) systems have been developed for genetic and epigenetic
analyses in clinical applications because of advantages such as reduced sample size and …