Reactive oxygen species (ROS) are highly reactive chemical species containing oxygen,
controlled by both enzymatic and nonenzymatic antioxidant defense systems. In the heart …

Oxidative stress is a common denominator in the pathology of neurodegenerative disorders
such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral …

Although acute exposure of the heart to angiotensin (Ang II) produces physiological cardiac
hypertrophy and chronic exposure results in pathological hypertrophy, the signal …

atherosclerosis, hypertension, cardiac hypertrophy and remodeling, angiogenesis and
collateral formation, stroke, and heart failure. In this review, we discuss in detail the …

For a long time, superoxide generation by an NADPH oxidase was considered as an oddity
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …

Macrovascular complications of diabetes, including diabetic cardiovascular disease (CVD),
occur through a number of hyperglycaemia-induced mechanisms that include generation of …

Redox signaling refers to the specific and usually reversible oxidation/reduction modification
of molecules involved in cellular signaling pathways. In the heart, redox signaling regulates …

It has been 60 yr since the discovery of reactive oxygen species (ROS) in biology and the
beginning of the scientific community's attempt to understand the impact of the unpaired …

ST2 is an IL-1 receptor family member with transmembrane (ST2L) and soluble (sST2)
isoforms. sST2 is a mechanically induced cardiomyocyte protein, and serum sST2 levels …

Obesity is a complex disease characterized by excessive expansion of adipose tissue and is
an important risk factor for chronic diseases such as cardiovascular disorders, hypertension …