G protein-coupled receptor (GPCR) kinases (GRKs) are best known for their role in
homologous desensitization of GPCRs. GRKs phosphorylate activated receptors and …

Obese subjects often have hypertension and related cardiovascular and renal diseases, and
this has become a serious worldwide health problem. In obese subjects, impaired renal …

Dopamine is an important regulator of systemic blood pressure via multiple mechanisms. It
affects fluid and electrolyte balance by its actions on renal hemodynamics and epithelial ion …

Background—The cause and consequences of impaired adrenergic signaling in right
ventricular failure/hypertrophy (RVH) are poorly understood. We hypothesized that G protein …

Complex interactions between genes and environment result in a sodium-induced elevation
in blood pressure (salt sensitivity) and/or hypertension that lead to significant morbidity and …

Dopamine, which is synthesized in the kidney, independent of renal nerves, plays an
important role in the regulation of fluid and electrolyte balance and systemic blood pressure …

Fluid homeostasis, blood pressure and redox balance in the kidney are regulated by an
intricate interaction between local and systemic anti-natriuretic and natriuretic systems …

OBJECTIVE Insulin resistance is associated with the pathogenesis of metabolic disorders as
type 2 diabetes and obesity. Given the emerging role of signal transduction in these …

NADPH oxidases are the major sources of reactive oxygen species in cardiovascular,
neural, and kidney cells. The NADPH oxidase 5 (NOX5) gene is present in humans but not …

Individuals with metabolic syndrome exhibit insulin resistance and an attenuated functional
vasodilatory response to exercise. We have shown that impaired functional vasodilation in …