Asthma is a common heterogeneous disease with a complex pathophysiology that carries a
significant mortality rate and high morbidity. Current therapies based on inhaled …

Airway smooth muscle (ASM) plays an integral part in the pathophysiology of asthma. It is
responsible for acute bronchoconstriction, which is potentiated by constrictor …

Asthma is an inflammatory disorder of the conducting airways that has strong association
with allergic sensitization. The disease is characterized by a polarized Th-2 (T-helper-2) …

Severe asthma is “asthma which requires treatment with high dose inhaled corticosteroids
(ICS) plus a second controller (and/or systemic corticosteroids) to prevent it from becoming …

Fibrocytes are circulating mesenchymal progenitor cells that participate in tissue responses
to injury and invasion. Accumulating knowledge from animal models regarding the …

There has been an increased understanding, over the past 2 decades, that asthma is a
chronic, immunologically mediated condition with a disturbance of the normal airway repair …

Fibrocytes contribute to the fibrotic changes most frequently observed in forms of asthma
where inflammation is driven by T helper type 2 (Th2) cells. The mechanisms that regulate …

Skin fibrotic remodeling is a major feature in human atopic dermatitis (AD). Inflammation and
tissue fibrosis are common consequences of Th2 responses. Elevated IL-13 and thymic …

Severe asthma is a heterogeneous disease with substantial unmet clinical need. Airway
damage and remodelling is a consequence of complex host–environment interactions and …

Chronic allergic asthma is characterized by Th2-polarized inflammation and leads to airway
remodeling and fibrosis but the mechanisms involved are not clear. To determine whether …