Arachidonic acid-derived prostaglandins not only contribute to the development of
inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of …

Peripheral mediators can contribute to the development and maintenance of inflammatory
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …

The thermo‐transient receptor potentials (TRPs), a recently discovered family of ion
channels activated by temperature, are expressed in primary sensory nerve terminals where …

The EP4 prostanoid receptor is one of four receptor subtypes for prostaglandin E2. It
belongs to the family of G protein–coupled receptors. It was originally identified, similar to …

A high-intensity potentially tissue-injuring stimulus generates a homotopic response to
escape the stimulus and is associated with an affective phenotype considered to represent …

Mechanisms of inflammatory pain are not fully understood. We investigated the role of
TRPV1 (transient receptor potential subtype V1) and TNF-α, two critical mediators for …

TRPV1 is a well-characterised channel expressed by a subset of peripheral sensory
neurons involved in pain sensation and also at a number of other neuronal and non …

The formation of multiprotein complexes is a repeated theme in biology ranging from the
regulation of the extracellular signal-regulated kinase and cAMP signaling pathways to the …

Sensory nerves are equipped with receptors and ion channels that allow them to detect and
respond to diverse chemical, mechanical, and thermal stimuli. These sensory proteins …

Mitochondrial fission and fusion impact numerous cellular functions and neurons are
particularly sensitive to perturbations in mitochondrial dynamics. Here we describe that male …