Stress induced microglial activation contributes to depression
B Li, W Yang, T Ge, Y Wang, R Cui - Pharmacological research, 2022 - Elsevier
Major depressive disorder (MDD) is a debilitating neuropsychological disorder, which has
caused serious health and socio-economic burdens worldwide. A growing body of evidence …
caused serious health and socio-economic burdens worldwide. A growing body of evidence …
Astrocyte regulation of synaptic signaling in psychiatric disorders
Over the last 15 years, the field of neuroscience has evolved toward recognizing the critical
role of astroglia in shaping neuronal synaptic activity and along with the pre-and …
role of astroglia in shaping neuronal synaptic activity and along with the pre-and …
[HTML][HTML] NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression
S Li, Y Sun, M Song, Y Song, Y Fang, Q Zhang, X Li… - JCI insight, 2021 - ncbi.nlm.nih.gov
Emerging evidence suggests that astrocyte loss is one of the most important pathological
features in the hippocampus of patients with major depressive disorder (MDD) and …
features in the hippocampus of patients with major depressive disorder (MDD) and …
Identification of transcriptome alterations in the prefrontal cortex, hippocampus, amygdala and hippocampus of suicide victims
Suicide is one of the leading causes of death globally for all ages, and as such presents a
very serious problem for clinicians worldwide. However, the underlying neurobiological …
very serious problem for clinicians worldwide. However, the underlying neurobiological …
Glial cell abnormalities in major psychiatric diseases: A systematic review of postmortem brain studies
SH Liu, Y Du, L Chen, Y Cheng - Molecular neurobiology, 2022 - Springer
There have been a large number of reports about glial cell dysfunction being related to
major psychiatric diseases such as schizophrenia (SCZ), bipolar disorder (BD), and major …
major psychiatric diseases such as schizophrenia (SCZ), bipolar disorder (BD), and major …
Widespread decrease of cerebral vimentin-immunoreactive astrocytes in depressed suicides
LA O'Leary, C Belliveau, MA Davoli, JC Ma… - Frontiers in …, 2021 - frontiersin.org
Post-mortem investigations have implicated cerebral astrocytes immunoreactive (-IR) for
glial fibrillary acidic protein (GFAP) in the etiopathology of depression and suicide. However …
glial fibrillary acidic protein (GFAP) in the etiopathology of depression and suicide. However …
The positive effects of running exercise on hippocampal astrocytes in a rat model of depression
Y Li, Y Luo, J Tang, X Liang, J Wang, Q Xiao… - Translational …, 2021 - nature.com
Running exercise has been shown to alleviate depressive symptoms, but the mechanism of
its antidepressant effect is still unclear. Astrocytes are the predominant cell type in the brain …
its antidepressant effect is still unclear. Astrocytes are the predominant cell type in the brain …
NLRP3 inflammatory pathway. Can we unlock depression?
GG Jahromi, S Razi, N Rezaei - Brain Research, 2023 - Elsevier
Depression holds the title of the largest contributor to worldwide disability, with the numbers
expected to continue growing. Currently, there are neither reliable biomarkers for the …
expected to continue growing. Currently, there are neither reliable biomarkers for the …
A Review of Research on the Association between Neuron–Astrocyte Signaling Processes and Depressive Symptoms
J Yao, C Chen, Y Guo, Y Yang, X Liu, S Chu… - International Journal of …, 2023 - mdpi.com
Depression is a mental illness that has a serious negative impact on physical and mental
health. The pathophysiology of depression is still unknown, and therapeutic medications …
health. The pathophysiology of depression is still unknown, and therapeutic medications …
Role of astrocytes in major neuropsychiatric disorders
Astrocytes are the primary homeostatic cells of the central nervous system, essential for
normal neuronal development and function, metabolism and response to injury and …
normal neuronal development and function, metabolism and response to injury and …