ImmunoPET: concept, design, and applications

W Wei, ZT Rosenkrans, J Liu, G Huang, QY Luo… - Chemical …, 2020 - ACS Publications
Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade

RB Patel, R Hernandez, P Carlson… - Science translational …, 2021 - science.org
Molecular and cellular effects of radiotherapy on tumor microenvironment (TME) can help
prime and propagate antitumor immunity. We hypothesized that delivering radiation to all …

Imaging using radiolabelled targeted proteins: Radioimmunodetection and beyond

J Garousi, A Orlova, FY Frejd, V Tolmachev - EJNMMI radiopharmacy and …, 2020 - Springer
The use of radiolabelled antibodies was proposed in 1970s for staging of malignant
tumours. Intensive research established chemistry for radiolabelling of proteins and …

Py-macrodipa: a Janus chelator capable of binding medicinally relevant rare-earth radiometals of disparate sizes

A Hu, E Aluicio-Sarduy, V Brown… - Journal of the …, 2021 - ACS Publications
Nuclear medicine leverages different types of radiometals for disease diagnosis and
treatment, but these applications usually require them to be stably chelated. Given the often …

Radiometals for imaging and theranostics, current production, and future perspectives

R Mikolajczak, NP van der Meulen… - Journal of Labelled …, 2019 - Wiley Online Library
The aim of this review is to make the reader familiar with currently available radiometals,
their production modes, capacities, and quality concerns related to their medical use, as well …

Cyclotron production of 43Sc and 44gSc from enriched 42CaO, 43CaO, and 44CaO targets

KV Becker, E Aluicio-Sarduy, T Bradshaw… - Frontiers in …, 2023 - frontiersin.org
Introduction: 43Sc and 44gSc are both positron-emitting radioisotopes of scandium with
suitable half-lives and favorable positron energies for clinical positron emission tomography …

90Y-NM600 targeted radionuclide therapy induces immunologic memory in syngeneic models of T-cell Non-Hodgkin's Lymphoma

R Hernandez, KL Walker, JJ Grudzinski… - Communications …, 2019 - nature.com
Finding improved therapeutic strategies against T-cell Non-Hodgkin's Lymphoma (NHL)
remains an unmet clinical need. We implemented a theranostic approach employing a tumor …

Safety and feasibility of an in situ vaccination and immunomodulatory targeted radionuclide combination immuno-radiotherapy approach in a comparative …

K Magee, IR Marsh, MM Turek, J Grudzinski… - PLoS …, 2021 - journals.plos.org
Rationale Murine syngeneic tumor models have revealed efficacious systemic antitumor
responses following primary tumor in situ vaccination combined with targeted radionuclide …

Production and in vivo PET/CT imaging of the theranostic pair 132/135La

E Aluicio-Sarduy, R Hernandez, AP Olson… - Scientific reports, 2019 - nature.com
The present study describes a novel method for the low energy cyclotron production and
radiochemical isolation of no-carrier-added 132/135La3+ from bulk natBa. This separation …

Prospects for the production of radioisotopes and radiobioconjugates for theranostics

J Choiński, M Łyczko - Bio-Algorithms and Med-Systems, 2022 - degruyter.com
The development of diagnostic methods in medicine as well as the progress in the synthesis
of biologically active compounds allows the use of selected radioisotopes for the …