Prevention and treatment of papillomavirus-related cancers through immunization

IH Frazer, GR Leggatt… - Annual review of …, 2011 - annualreviews.org
Cervical and other anogenital cancers are initiated by infection with one of a small group of
human papillomaviruses (HPV). Virus-like particle-based vaccines have recently been …

[HTML][HTML] HPV-16 E5 down-regulates expression of surface HLA class I and reduces recognition by CD8 T cells

MS Campo, SV Graham, MS Cortese, GH Ashrafi… - Virology, 2010 - Elsevier
HPV-16 is the major causes of cervical cancer. Persistence of infection is a necessary event
for progression of the infection to cancer. Among other factors, virus persistence is due the …

The immunosuppressive ligands PD-L1 and CD200 are linked in AML T-cell immunosuppression: identification of a new immunotherapeutic synapse

SJ Coles, MN Gilmour, R Reid, S Knapper, AK Burnett… - Leukemia, 2015 - nature.com
Long-term remission in acute myeloid leukemia (AML) is generally not durable only being
achieved in o50% of patients. 1 Consequently there is a need to establish new treatments to …

HPV-16 E6 and E7 protein T cell epitopes prediction analysis based on distributions of HLA-A loci across populations: an in silico approach

Y Yao, W Huang, X Yang, W Sun, X Liu, W Cun, Y Ma - Vaccine, 2013 - Elsevier
Human papillomavirus type 16 (HPV-16) is the most prevalent virus in human cervical
cancers, as it is present in more than half of all cases. Many studies have found continued …

Detection of human papillomavirus type 18 E6 and E7‐specific CD4+ T‐helper 1 immunity in relation to health versus disease

MJP Welters, P van der Logt… - … journal of cancer, 2006 - Wiley Online Library
The most common high‐risk human papillomavirus types, HPV16 and 18, differ markedly
with respect to their interaction with the host. Clearance of HPV18 infections generally takes …

Design of a synthetic long peptide vaccine targeting HPV-16 and-18 using immunoinformatic methods

A Tîrziu, S Avram, L Mada, M Crișan-Vida, C Popovici… - Pharmaceutics, 2023 - mdpi.com
Human papillomavirus types 16 and 18 cause the majority of cervical cancers worldwide.
Despite the availability of three prophylactic vaccines based on virus-like particles (VLP) of …

Ubiquitination in host immune response to human papillomavirus infection

Q Zhou, K Zhu, H Cheng - Archives of dermatological research, 2011 - Springer
Human papillomavirus (HPV) infection with low-risk or high-risk subtypes is very common.
Infection with HPVs is often a major causative factor for the development of cutaneous …

Synthetic peptides with inadvertent chemical modifications can activate potentially autoreactive T cells

S Man, JE Redman, DL Cross, DK Cole… - The Journal of …, 2021 - journals.aai.org
The human CD8+ T cell clone 6C5 has previously been shown to recognize the tert-butyl-
modified Bax 161–170 peptide LLSY (3-tBu) FGTPT presented by HLA-A* 02: 01. This …

Activated B cells mediate efficient expansion of rare antigen-specific T cells

C Zentz, M Wiesner, S Man, B Frankenberger… - Human immunology, 2007 - Elsevier
Potent professional antigen-presenting cells (APC) are essential tools to activate and
expand antigen-specific T cells in vitro for use in adoptive immunotherapy. CD40-activated B …

A novel tumor antigen derived from enhanced degradation of bax protein in human cancers

CT Nunes, KL Miners, G Dolton, C Pepper, C Fegan… - Cancer research, 2011 - AACR
Cancer cells frequently exhibit defects in apoptosis, which contribute to increased survival
and chemotherapeutic resistance. For example, genetic mutations or abnormal proteasomal …