Sex differences in traumatic brain injury: what we know and what we should know

RP Gupte, WM Brooks, RR Vukas, JD Pierce… - Journal of …, 2019 - liebertpub.com
There is growing recognition of the problem of male bias in neuroscience research,
including in the field of traumatic brain injury (TBI) where fewer women than men are …

Estrogens as neuroprotectants: estrogenic actions in the context of cognitive aging and brain injury

EB Engler-Chiurazzi, CM Brown, JM Povroznik… - Progress in …, 2017 - Elsevier
There is ample empirical evidence to support the notion that the biological impacts of
estrogen extend beyond the gonads to other bodily systems, including the brain and …

Sexual dimorphism in the inflammatory response to traumatic brain injury

S Villapol, DJ Loane, MP Burns - Glia, 2017 - Wiley Online Library
The activation of resident microglial cells, alongside the infiltration of peripheral
macrophages, are key neuroinflammatory responses to traumatic brain injury (TBI) that are …

Sex differences in outcome after mild traumatic brain injury

JJ Bazarian, B Blyth, S Mookerjee, H He… - Journal of …, 2010 - liebertpub.com
The objective of this study was to estimate the independent association of sex with outcome
after mild traumatic brain injury (mTBI). We performed an analysis of a subset of an …

Sex differences in acute neuroinflammation after experimental traumatic brain injury are mediated by infiltrating myeloid cells

SJ Doran, RM Ritzel, EP Glaser, RJ Henry… - Journal of …, 2019 - liebertpub.com
The inflammatory response to moderate-severe controlled cortical impact (CCI) in adult male
mice has been shown to exhibit greater glial activation compared with age-matched female …

Brain neurotrauma: molecular, neuropsychological, and rehabilitation aspects

FH Kobeissy - 2015 - books.google.com
Every year, an estimated 1.7 million Americans sustain brain injury. Long-term disabilities
impact nearly half of moderate brain injury survivors and nearly 50,000 of these cases result …

Sex-related responses after traumatic brain injury: Considerations for preclinical modeling

CB Späni, DJ Braun, LJ Van Eldik - Frontiers in neuroendocrinology, 2018 - Elsevier
Traumatic brain injury (TBI) has historically been viewed as a primarily male problem, since
men are more likely to experience a TBI because of more frequent participation in activities …

Menstrual phase as predictor of outcome after mild traumatic brain injury in women

K Wunderle, KM Hoeger, E Wasserman… - The Journal of head …, 2014 - journals.lww.com
Objective: To determine whether menstrual cycle phase in women at the time of mild
traumatic brain injury (mTBI) predicts 1-month outcomes. Setting: Six emergency …

Animal modelling of traumatic brain injury in preclinical drug development: where do we go from here?

N Marklund, L Hillered - British journal of pharmacology, 2011 - Wiley Online Library
Traumatic brain injury (TBI) is the leading cause of death and disability in young adults.
Survivors of TBI frequently suffer from long‐term personality changes and deficits in …

Persistent cognitive dysfunction after traumatic brain injury: a dopamine hypothesis

JW Bales, AK Wagner, AE Kline, CE Dixon - Neuroscience & Biobehavioral …, 2009 - Elsevier
Traumatic brain injury (TBI) represents a significant cause of death and disability in
industrialized countries. Of particular importance to patients the chronic effect that TBI has on …