Antibodies are highly potent therapeutic scaffolds with more than a hundred different
products approved on the market. Successful development of antibody-based drugs …

The MHC class I-related receptor FcRn serves multiple roles ranging from the regulation of
levels of IgG isotype antibodies and albumin throughout the body to the delivery of antigen …

Background The near impermeability of the blood-brain barrier (BBB) and the unique
neuroimmune environment of the CNS prevents the effective use of antibodies in …

The extracellular adenosine triphosphate (ATP) concentration is highly elevated in the tumor
microenvironment (TME) and remains tightly regulated in normal tissues. Using phage …

Monoclonal IgG antibodies are the fastest growing class of biologics, but large differences
exist in their plasma half-life in humans. Thus, to design IgG antibodies with favorable …

Therapeutic antibodies are instrumental in improving the treatment outcome for certain
disease conditions. However, to enhance their efficacy and specificity, many efforts are …

As an essential modulator of IgG disposition, the neonatal Fc receptor (FcRn) governs the
pharmacokinetics and functions many therapeutic modalities. In this review, we thoroughly …

The rising cost of global healthcare provision and new approaches to managing disease are
driving the development of low-cost biosensing modalities, such as label-free photonic …

Immunoglobulin G (IgG) antibodies are a critical component of the adaptive immune system,
binding to and neutralizing pathogens and other foreign substances. Recent advances in …

Modulating the complement system is a promising strategy in drug discovery for disorders
with uncontrolled complement activation. Although some of these disorders can be …