Cancer pain, especially pain caused by metastasis to bone, is a severe type of pain, and
unless the cause and consequences can be resolved, the pain will become chronic. As …

Animal models are pivotal for understanding the mechanism of neuropathic pain and
development of effective therapy for its optimal management. A battery of neuropathic pain …

Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

As a result of significant improvements in current therapies, the life expectancy of cancer
patients with bone metastases has dramatically improved. Unfortunately, these patients …

Chronic pain, especially neuropathic pain and cancer pain, is often not adequately treated
by currently available analgesics. Animal models provide pivotal systems for preclinical …

Materials and Methods Adult male 20-to 30-g C3H/He mice (Harlan, Indianapolis, IN) were
used in the experiments in accordance with the Ethical Guidelines for Investigations of …

Many known painkillers are not always effective in the therapy of chronic neuropathic pain
manifested by hyperalgesia and tactile allodynia. The mechanisms underlying neuropathic …

Ongoing and breakthrough pain is a primary concern for the cancer patient. Although the
etiology of cancer pain remains unclear, animal models of cancer pain have allowed …

The mRNA transcript of the human STMN2 gene, encoding for stathmin-2 protein (also
called SCG10), is profoundly impacted by TAR DNA-binding protein 43 (TDP-43) loss of …

Pain is one of the most severe and debilitating symptoms associated with several forms of
cancer,. Various types of carcinomas and sarcomas metastasize to skeletal bones and …