Systemic sclerosis (SSc) is a rare multisystem autoimmune disease, characterized by
fibrosis, vasculopathy, and autoimmunity. Recent advances have highlighted the significant …

COVID-19 shares the feature of autoantibody production with systemic autoimmune
diseases. In order to understand the role of these immune globulins in the pathogenesis of …

Most patients with Post COVID Syndrome (PCS) present with a plethora of symptoms without
clear evidence of organ dysfunction. A subset of them fulfills diagnostic criteria of myalgic …

Systemic sclerosis (SSc) is a complex, multiorgan, autoimmune disease. Lung fibrosis
occurs in∼ 80% of patients with SSc; 25% to 30% develop progressive interstitial lung …

Autoantibodies have been associated with autoimmune diseases. However, studies have
identified autoantibodies in healthy donors (HD) who do not develop autoimmune disorders …

Chronic inflammation and fibrosis can result from inappropriately activated immune
responses that are mediated by macrophages. Macrophages can acquire memory-like …

Background Systemic sclerosis-interstitial lung disease (SSc-ILD) is the leading cause of
death in patients with SSc. There is an unmet need for predictive biomarkers to identify …

Expressions of G protein-coupled receptors (GPCR) on immune and tissue resident cells are
the consequence of the cellular environment, which is highly variable. As discussed here …

Allosteric regulation is critical for the functioning of G protein-coupled receptors (GPCRs)
and their signaling pathways. Endogenous allosteric regulators of GPCRs are simple ions …

Systemic sclerosis (SSc) is a chronic, multisystem connective tissue, and autoimmune
disease with the highest case-specific mortality and complications among rheumatic …