Fibromyalgia: pathogenesis, mechanisms, diagnosis and treatment options update

R Siracusa, RD Paola, S Cuzzocrea… - International journal of …, 2021 - mdpi.com
Fibromyalgia is a syndrome characterized by chronic and widespread musculoskeletal pain,
often accompanied by other symptoms, such as fatigue, intestinal disorders and alterations …

Innovations and advances in modelling and measuring pain in animals

KE Sadler, JS Mogil, CL Stucky - Nature Reviews Neuroscience, 2022 - nature.com
Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …

Neurobiology of fibromyalgia and chronic widespread pain

KA Sluka, DJ Clauw - Neuroscience, 2016 - Elsevier
Fibromyalgia is the current term for chronic widespread musculoskeletal pain for which no
alternative cause can be identified. The underlying mechanisms, in both human and animal …

Does exercise increase or decrease pain? Central mechanisms underlying these two phenomena

LV Lima, TSS Abner, KA Sluka - The Journal of physiology, 2017 - Wiley Online Library
Exercise is an integral part of the rehabilitation of patients suffering a variety of chronic
musculoskeletal conditions, such as fibromyalgia, chronic low back pain and myofascial …

Sex differences in pain

RE Sorge, SK Totsch - Journal of neuroscience research, 2017 - Wiley Online Library
Females greatly outnumber males as sufferers of chronic pain. Although social and
psychological factors certainly play a role in the differences in prevalence and incidence …

Exercise-induced pain and analgesia? Underlying mechanisms and clinical translation

KA Sluka, L Frey-Law, MH Bement - Pain, 2018 - journals.lww.com
Physical inactivity or a sedentary lifestyle is a significant health concern worldwide. The
Centers for Disease Control (CDC) recommends 150 minutes per week of moderate to …

Sex differences in neuroimmune and glial mechanisms of pain

AM Gregus, IS Levine, KA Eddinger, TL Yaksh… - Pain, 2021 - journals.lww.com
Pain is the primary motivation for seeking medical care. Although pain may subside as
inflammation resolves or an injury heals, it is increasingly evident that persistency of the pain …

[HTML][HTML] Cannabinoids and the endocannabinoid system in fibromyalgia: A review of preclinical and clinical research

SL Bourke, AK Schlag, SE O'Sullivan, DJ Nutt… - Pharmacology & …, 2022 - Elsevier
Characterised by chronic widespread musculoskeletal pain, generalised hyperalgesia, and
psychological distress, fibromyalgia (FM) is a significant unmet clinical need. The …

Central sensitization and changes in conditioned pain modulation in people with chronic nonspecific low back pain: a case–control study

JB Corrêa, LOP Costa, NTB de Oliveira… - Experimental brain …, 2015 - Springer
Quantitative sensory testing is widely used in human research to investigate the state of the
peripheral and central nervous system contributions in pain processing. It is a valuable tool …

Animal models of fibromyalgia: What is the best choice?

ES Brum, G Becker, MFP Fialho, SM Oliveira - Pharmacology & …, 2022 - Elsevier
Fibromyalgia (FM) is a complex syndrome, with an indefinite aetiology and intricate
pathophysiology that affects 2–3% of the world population. From the beginning of the 2000s …