Deazaflavin cofactors enhance the metabolic flexibility of microorganisms by catalyzing a
wide range of challenging enzymatic redox reactions. While structurally similar to riboflavin …

The genus Mycobacterium comprises a group of obligately aerobic bacteria that have
adapted to inhabit a wide range of intracellular and extracellular environments …

The cohort of the ammonia‐oxidizing archaea (AOA) of the phylum Thaumarchaeota is a
diverse, widespread and functionally important group of microorganisms in many …

M. tuberculosis (Mtb) survives a hostile environment within the host that is shaped in part by
oxidative stress. The mechanisms used by Mtb to resist these stresses remain ill-defined …

Aflatoxins are polyaromatic mycotoxins that contaminate a range of food crops as a result of
fungal growth and contribute to serious health problems in the developing world because of …

Our inability to predict which mutations could result in antibiotic resistance has made it
difficult to rapidly identify the emergence of resistance, identify pre-existing resistant …

Abstract Geothermal systems in Yellowstone National Park (YNP) provide an outstanding
opportunity to understand the origin and evolution of metabolic processes necessary for life …

Many bacteria and archaea produce the redox cofactor F420. F420 is structurally similar to
the cofactors FAD and FMN but is catalytically more similar to NAD and NADP. These …

M ycobacterium tuberculosis (Mtb) is an aerobic bacterium that persists intracellularly in host
macrophages and has evolved diverse mechanisms to combat and survive oxidative stress …

Iron-sulfur (Fe-S) biogenesis requires multiprotein assembly systems, SUF and ISC, in most
prokaryotes. M. tuberculosis (Mtb) encodes a complete SUF system, the depletion of which …