Stroke is a leading cause of disability, dementia and death worldwide. Approximately 70% of
deaths from stroke and 87% of stroke-related disability occur in low-income and middle …

Genetic coding variants in APOL1, which encodes apolipoprotein L1 (APOL1), were
identified in 2010 and are relatively common among individuals of sub-Saharan African …

Background: Given the increasing worldwide prevalence of chronic kidney disease (CKD), it
is critical to decrease the associated risk of debilitating vascular complications, including …

Stroke is the second leading cause of death worldwide and a complex, heterogeneous
condition. In this review, we provide an overview of the current knowledge on monogenic …

Chronic kidney disease (CKD), defined by low estimated glomerular filtration rate (eGFR),
contributes to global morbidity and mortality. Here we conduct a transethnic Genome-Wide …

The burden of chronic kidney disease (CKD) is rapidly rising in developing countries due to
astronomical increases in key risk factors including hypertension and diabetes. We sought to …

With increased numbers of older people a higher burden of neurological disorders
worldwide is predicted. Stroke and other cerebrovascular diseases do not necessarily …

Objective Two apolipoprotein L1 (APOL1) risk variants (RV) are enriched in sub-Saharan
African populations due to conferred resistance to Trypanosoma brucei. These variants …

Background and Purpose—The interplay between sex and the dominant risk factors for
stroke occurrence in sub-Saharan Africa has not been clearly delineated. We compared the …

Background: Genetic variants in APOL1 are a major contributor to the increased risk of
kidney disease in people of recent African ancestry. Summary: Two alleles in the APOL1 …